| KOCURKOVÁ, Anna, Kristina NESPOROVA, Miriam SANDANUSOVÁ, Michaela KERBEROVÁ, Kateřina LEHKÁ, Vladimír VELEBNÝ, Lukáš KUBALA and Gabriela AMBROŽOVÁ. Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions. Biomolecules. MDPI, 2022, vol. 12, No 1, p. 1-17. ISSN 2218-273X. Available from: https://dx.doi.org/10.3390/biom12010045. |
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@article{1835118,
author = {Kocurková, Anna and Nesporova, Kristina and Sandanusová, Miriam and Kerberová, Michaela and Lehká, Kateřina and Velebný, Vladimír and Kubala, Lukáš and Ambrožová, Gabriela},
article_number = {1},
doi = {http://dx.doi.org/10.3390/biom12010045},
keywords = {peritoneal adhesion; fibrosis; hyaluronan; mesothelial cell; metabolism; inflammation; mesothelial-to-mesenchymal transition},
language = {eng},
issn = {2218-273X},
journal = {Biomolecules},
title = {Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions},
url = {https://www.mdpi.com/2218-273X/12/1/45},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 1835118
AU - Kocurková, Anna - Nesporova, Kristina - Sandanusová, Miriam - Kerberová, Michaela - Lehká, Kateřina - Velebný, Vladimír - Kubala, Lukáš - Ambrožová, Gabriela
PY - 2022
TI - Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions
JF - Biomolecules
VL - 12
IS - 1
SP - 1-17
EP - 1-17
PB - MDPI
SN - 2218273X
KW - peritoneal adhesion
KW - fibrosis
KW - hyaluronan
KW - mesothelial cell
KW - metabolism
KW - inflammation
KW - mesothelial-to-mesenchymal transition
UR - https://www.mdpi.com/2218-273X/12/1/45
N2 - Formation of peritoneal adhesions (PA) is one of the major complications following intra-abdominal surgery. It is primarily caused by activation of the mesothelial layer and underlying tissues in the peritoneal membrane resulting in the transition of mesothelial cells (MCs) and fibroblasts to a pro-fibrotic phenotype. Pro-fibrotic transition of MCs-mesothelial-to-mesenchymal transition (MMT), and fibroblasts activation to myofibroblasts are interconnected to changes in cellular metabolism and culminate in the deposition of extracellular matrix (ECM) in the form of fibrotic tissue between injured sides in the abdominal cavity. However, ECM is not only a mechanical scaffold of the newly synthetized tissue but reciprocally affects fibrosis development. Hyaluronan (HA), an important component of ECM, is a non-sulfated glycosaminoglycan consisting of N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcUA) that can affect the majority of processes involved in PA formation. This review considers the role of endogenously produced HA in the context of different fibrosis-related pathologies and its overlap in the development of PA.
ER -
KOCURKOVÁ, Anna, Kristina NESPOROVA, Miriam SANDANUSOVÁ, Michaela KERBEROVÁ, Kateřina LEHKÁ, Vladimír VELEBNÝ, Lukáš KUBALA and Gabriela AMBROŽOVÁ. Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions. \textit{Biomolecules}. MDPI, 2022, vol.~12, No~1, p.~1-17. ISSN~2218-273X. Available from: https://dx.doi.org/10.3390/biom12010045.
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