Incorporating natural anti-inflammatory compounds into yeast
glucan particles increases their bioactivity in vitro

J 2021

Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro

SALAMUNOVA, P., L. CUPALOVÁ, M. MAJERSKA, Jakub TREML, G. RUPHUY et. al.

Basic information

Original name

Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro

Authors

SALAMUNOVA, P., L. CUPALOVÁ (203 Czech Republic), M. MAJERSKA, Jakub TREML (203 Czech Republic, belonging to the institution), G. RUPHUY, Karel ŠMEJKAL (203 Czech Republic, belonging to the institution), F. STEPANEK, J. HANUS and J. HOSEK (guarantor)

Edition

International journal of biological macromolecules, AMSTERDAM, Elsevier, 2021, 0141-8130

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 8.025

RIV identification code

RIV/00216224:14160/21:00124219

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1016/j.ijbiomac.2020.12.107

UT WoS

000609211300044

Keywords in English

beta-glucan microparticles; Drug carrier; Inflammation; Monocytes; Natural compounds; Pharmaceutical composite

Abstract

V originále

Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro. Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs+ bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared. Several of the natural compounds showed the beneficial effects of being combined with GPs. The materials prepared by spray drying showed greater activity than those made using a rotary evaporator. Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-kappa B/AP-1 and the secretion of the pro-inflammatory cytokine TNF alpha. (C) 2020 Elsevier B.V. All rights reserved.

Citovat

SALAMUNOVA, P., L. CUPALOVÁ, M. MAJERSKA, Jakub TREML, G. RUPHUY, Karel ŠMEJKAL, F. STEPANEK, J. HANUS and J. HOSEK. Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro. International journal of biological macromolecules. AMSTERDAM: Elsevier, 2021, vol. 169, No 2, p. 443-451. ISSN 0141-8130. Available from: https://dx.doi.org/10.1016/j.ijbiomac.2020.12.107.

@article{1835179,
   author = {Salamunova, P. and Cupalová, L. and Majerska, M. and Treml, Jakub and Ruphuy, G. and Šmejkal, Karel and Stepanek, F. and Hanus, J. and Hosek, J.},
   article_location = {AMSTERDAM},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.ijbiomac.2020.12.107},
   keywords = {beta-glucan microparticles; Drug carrier; Inflammation; Monocytes; Natural compounds; Pharmaceutical composite},
   language = {eng},
   issn = {0141-8130},
   journal = {International journal of biological macromolecules},
   title = {Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro},
   url = {https://www.sciencedirect.com/science/article/pii/S0141813020352740?via%3Dihub},
   volume = {169},
   year = {2021}
}

TY  - JOUR
ID  - 1835179
AU  - Salamunova, P. - Cupalová, L. - Majerska, M. - Treml, Jakub - Ruphuy, G. - Šmejkal, Karel - Stepanek, F. - Hanus, J. - Hosek, J.
PY  - 2021
TI  - Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro
JF  - International journal of biological macromolecules
VL  - 169
IS  - 2
SP  - 443-451
EP  - 443-451
PB  - Elsevier
SN  - 01418130
KW  - beta-glucan microparticles
KW  - Drug carrier
KW  - Inflammation
KW  - Monocytes
KW  - Natural compounds
KW  - Pharmaceutical composite
UR  - https://www.sciencedirect.com/science/article/pii/S0141813020352740?via%3Dihub
N2  - Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro. Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs+ bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared. Several of the natural compounds showed the beneficial effects of being combined with GPs. The materials prepared by spray drying showed greater activity than those made using a rotary evaporator. Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-kappa B/AP-1 and the secretion of the pro-inflammatory cytokine TNF alpha. (C) 2020 Elsevier B.V. All rights reserved.
ER  -

SALAMUNOVA, P., L. CUPALOVÁ, M. MAJERSKA, Jakub TREML, G. RUPHUY, Karel ŠMEJKAL, F. STEPANEK, J. HANUS and J. HOSEK. Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro. \textit{International journal of biological macromolecules}. AMSTERDAM: Elsevier, 2021, vol.~169, No~2, p.~443-451. ISSN~0141-8130. Available from: https://dx.doi.org/10.1016/j.ijbiomac.2020.12.107.

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