| DASH, A., B. BLASIAK, Boguslaw TOMANEK, Peter LATTA and FCJM. VAN VEGGEL. Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles. ACS APPLIED MATERIALS & INTERFACES. WASHINGTON: AMER CHEMICAL SOC, 2021, vol. 13, No 21, p. 24345-24355. ISSN 1944-8244. Available from: https://dx.doi.org/10.1021/acsami.0c19273. |
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@article{1836119,
author = {Dash, A. and Blasiak, B. and Tomanek, Boguslaw and Latta, Peter and van Veggel, FCJM.},
article_location = {WASHINGTON},
article_number = {21},
doi = {http://dx.doi.org/10.1021/acsami.0c19273},
keywords = {anti-PSMA; MRI; relaxivity; nanoparticle; paramagnetic; dysprosium; gadlinium; EPR},
language = {eng},
issn = {1944-8244},
journal = {ACS APPLIED MATERIALS & INTERFACES},
title = {Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles},
url = {https://pubs.acs.org/doi/10.1021/acsami.0c19273},
volume = {13},
year = {2021}
}
TY - JOUR
ID - 1836119
AU - Dash, A. - Blasiak, B. - Tomanek, Boguslaw - Latta, Peter - van Veggel, FCJM.
PY - 2021
TI - Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles
JF - ACS APPLIED MATERIALS & INTERFACES
VL - 13
IS - 21
SP - 24345-24355
EP - 24345-24355
PB - AMER CHEMICAL SOC
SN - 19448244
KW - anti-PSMA
KW - MRI
KW - relaxivity
KW - nanoparticle
KW - paramagnetic
KW - dysprosium
KW - gadlinium
KW - EPR
UR - https://pubs.acs.org/doi/10.1021/acsami.0c19273
N2 - We illustrate the development of NaDyF4-NaGdF4 core-shell nanoparticles (NPs) for targeting prostate cancer cells using a preclinical 9.4 T magnetic resonance imaging (MRI) of live animals. The NPs composed of paramagnetic Dy3+ and Gd3+ (T-2- and T-1-contrast agents, respectively) demonstrate proton relaxivities of r(1) = 20.2 mM(-1) s(-1) and r(2) = 32.3 mM(-1) s(-1) at clinical 3 T and r(1) = 9.4 mM(-1) s(-1) and r(2) = 144.7 mM(-1) s(-1) at preclinical 9.4 T. The corresponding relaxivity values per NP are r(1) = 19.4 x 105 mM(NP)(-1) s(-1) and r(2) = 33.0 x 10(5) mMNP(-1) s(-1) at 3 T and r(1) = 9.0 x 105 mM(NP)(-1) s(-1) and r(2) = 147.0 x 10(5) mM(NP)(-1) s(-1) at 9.4 T. In vivo active targeting of human prostate tumors grown in nude mice revealed docking of anti-prostate-specific membrane antigen (PSMA) antibody-tagged NPs at tumor sites post-24 h of their intravenous injection. On the other hand, in vivo passive targeting showed preferential accumulation of NPs at tumor sites only within 2 h of their injection, ascribed to the enhanced permeation and retention effect of the tumor. A biodistribution study employing the harvested organs of mice, post-24 h injection of NPs, quantified active targeting as nearly twice as efficient as passive targeting. These outcomes provide potential opportunities for noninvasive diagnosis using NaDyF4-NaGdF4 core-shell NPs for target-specific MRI.
ER -
DASH, A., B. BLASIAK, Boguslaw TOMANEK, Peter LATTA and FCJM. VAN VEGGEL. Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles. \textit{ACS APPLIED MATERIALS \&{}amp; INTERFACES}. WASHINGTON: AMER CHEMICAL SOC, 2021, vol.~13, No~21, p.~24345-24355. ISSN~1944-8244. Available from: https://dx.doi.org/10.1021/acsami.0c19273.
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