Copper(II) Phenanthroline-Based Complexes as Potential
AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

J 2022

Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

MASURI, Sebastiano, Petr VAŇHARA, Maria Grazia CABIDDU, Lukáš MORÁŇ, Josef HAVEL et. al.

Basic information

Original name

Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

Authors

MASURI, Sebastiano (guarantor), Petr VAŇHARA (203 Czech Republic, belonging to the institution), Maria Grazia CABIDDU, Lukáš MORÁŇ (203 Czech Republic, belonging to the institution), Josef HAVEL (203 Czech Republic, belonging to the institution), Enzo CADONI and Tiziana PIVETTA

Edition

Molecules, Basel, MDPI, 2022, 1420-3049

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10401 Organic chemistry

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14110/22:00125429

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/molecules27010049

UT WoS

000755482700001

Keywords in English

cancer; coordination compounds; copper; 1-10-phenanthroline; anticancer chemotherapy; chemoresistance; cell stress response

Abstract

V originále

Copper is an endogenous metal ion that has been studied to prepare a new antitumoral agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS production, in the promotion of tumor progression, metastasis, and angiogenesis, and has been found at high levels in serum and tissues of several types of human cancers. Under these circumstances, two strategies are commonly followed in the development of novel anticancer Copper-based drugs: the sequestration of free Copper ions and the synthesis of Copper complexes that trigger cell death. The latter strategy has been followed in the last 40 years and many reviews have covered the anticancer properties of a broad spectrum of Copper complexes, showing that the activity of these compounds is often multi factored. In this work, we would like to focus on the anticancer properties of mixed Cu(II) complexes bearing substituted or unsubstituted 1,10-phenanthroline based ligands and different classes of inorganic and organic auxiliary ligands. For each metal complex, information regarding the tested cell lines and the mechanistic studies will be reported and discussed. The exerted action mechanisms were presented according to the auxiliary ligand/s, the metallic centers, and the increasing complexity of the compound structures.

Links

MUNI/A/1390/2020, interní kód MU

Name: Analytická a fyzikální chemie ve výzkumu biologických, geologických a syntetických materiálů (Acronym: BIOGEOSYNT)

Investor: Masaryk University

MUNI/A/1689/2020, interní kód MU

Name: Zdroje pro tkáňové inženýrství 11 (Acronym: TissueEng 11)

Investor: Masaryk University

ROZV/28/LF23/2020, interní kód MU

Name: Objasněni vlivu ztráty TUSC3 na změnu fenotypových vlastnosti buněk ovariálního povrchového epitelu.

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

MASURI, Sebastiano, Petr VAŇHARA, Maria Grazia CABIDDU, Lukáš MORÁŇ, Josef HAVEL, Enzo CADONI and Tiziana PIVETTA. Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action. Molecules. Basel: MDPI, 2022, vol. 27, No 1, p. 1-26. ISSN 1420-3049. Available from: https://dx.doi.org/10.3390/molecules27010049.

@article{1836617,
   author = {Masuri, Sebastiano and Vaňhara, Petr and Cabiddu, Maria Grazia and Moráň, Lukáš and Havel, Josef and Cadoni, Enzo and Pivetta, Tiziana},
   article_location = {Basel},
   article_number = {1},
   doi = {http://dx.doi.org/10.3390/molecules27010049},
   keywords = {cancer; coordination compounds; copper; 1-10-phenanthroline; anticancer chemotherapy; chemoresistance; cell stress response},
   language = {eng},
   issn = {1420-3049},
   journal = {Molecules},
   title = {Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action},
   url = {https://www.mdpi.com/1420-3049/27/1/49/htm},
   volume = {27},
   year = {2022}
}

TY  - JOUR
ID  - 1836617
AU  - Masuri, Sebastiano - Vaňhara, Petr - Cabiddu, Maria Grazia - Moráň, Lukáš - Havel, Josef - Cadoni, Enzo - Pivetta, Tiziana
PY  - 2022
TI  - Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action
JF  - Molecules
VL  - 27
IS  - 1
SP  - 1-26
EP  - 1-26
PB  - MDPI
SN  - 14203049
KW  - cancer
KW  - coordination compounds
KW  - copper
KW  - 1-10-phenanthroline
KW  - anticancer chemotherapy
KW  - chemoresistance
KW  - cell stress response
UR  - https://www.mdpi.com/1420-3049/27/1/49/htm
N2  - Copper is an endogenous metal ion that has been studied to prepare a new antitumoral agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS production, in the promotion of tumor progression, metastasis, and angiogenesis, and has been found at high levels in serum and tissues of several types of human cancers. Under these circumstances, two strategies are commonly followed in the development of novel anticancer Copper-based drugs: the sequestration of free Copper ions and the synthesis of Copper complexes that trigger cell death. The latter strategy has been followed in the last 40 years and many reviews have covered the anticancer properties of a broad spectrum of Copper complexes, showing that the activity of these compounds is often multi factored. In this work, we would like to focus on the anticancer properties of mixed Cu(II) complexes bearing substituted or unsubstituted 1,10-phenanthroline based ligands and different classes of inorganic and organic auxiliary ligands. For each metal complex, information regarding the tested cell lines and the mechanistic studies will be reported and discussed. The exerted action mechanisms were presented according to the auxiliary ligand/s, the metallic centers, and the increasing complexity of the compound structures.
ER  -

MASURI, Sebastiano, Petr VAŇHARA, Maria Grazia CABIDDU, Lukáš MORÁŇ, Josef HAVEL, Enzo CADONI and Tiziana PIVETTA. Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action. \textit{Molecules}. Basel: MDPI, 2022, vol.~27, No~1, p.~1-26. ISSN~1420-3049. Available from: https://dx.doi.org/10.3390/molecules27010049.

Detailed Information on Publication Record