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@article{1836825, author = {Věžník, Jakub and Konhefr, Martin and Fohlerová, Zdenka and Lacina, Karel}, article_location = {NEW YORK}, article_number = {November 2021}, doi = {http://dx.doi.org/10.1016/j.jinorgbio.2021.111561}, keywords = {Aminoferrocene; Redox-dependent cytotoxicity; ROS-activated prodrugs; Ferrocenyliminoboronates; MG-63; Electrochemical characterization}, language = {eng}, issn = {0162-0134}, journal = {Journal of Inorganic Biochemistry}, title = {Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates}, url = {https://www.sciencedirect.com/science/article/pii/S0162013421002087?via%3Dihub}, volume = {224}, year = {2021} }
TY - JOUR ID - 1836825 AU - Věžník, Jakub - Konhefr, Martin - Fohlerová, Zdenka - Lacina, Karel PY - 2021 TI - Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates JF - Journal of Inorganic Biochemistry VL - 224 IS - November 2021 SP - 1-8 EP - 1-8 PB - Elsevier SN - 01620134 KW - Aminoferrocene KW - Redox-dependent cytotoxicity KW - ROS-activated prodrugs KW - Ferrocenyliminoboronates KW - MG-63 KW - Electrochemical characterization UR - https://www.sciencedirect.com/science/article/pii/S0162013421002087?via%3Dihub N2 - Four ferrocene derivatives - ferrocenecarboxylic acid, ferrocenium salt, ferroceneboronic acid, and amino-ferrocene - were characterized electrochemically, and their cytotoxicity was probed using cancer cells (line MG -63). We related the observed cytotoxicity with the determined redox potentials of these four ferrocenes - ami-noferrocene with its lowest redox potential exhibited the highest cytotoxicity. Thus, we synthesized four de-rivatives consisting of aminoferrocene and phenylboronic acid residue with the intent to employ them as ROS-activated prodrugs (ROS - reactive oxygen species). We characterized them and studied their time-dependent stability in aqueous environments. Then, we performed electrochemical measurements at oxidative conditions to confirm ROS-responsivity of the synthesized molecules. Finally, the cytotoxicity of the synthesized molecules was tested using cancer MG-63 cells and noncancerous NIH-3T3 cells. The experiments revealed sought behaviour, especially for para-regioisomers of synthesized ferrocenyliminoboronates. ER -
VĚŽNÍK, Jakub, Martin KONHEFR, Zdenka FOHLEROVÁ a Karel LACINA. Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates. \textit{Journal of Inorganic Biochemistry}. NEW YORK: Elsevier, 2021, roč.~224, November 2021, s.~1-8. ISSN~0162-0134. Dostupné z: https://dx.doi.org/10.1016/j.jinorgbio.2021.111561.
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