JAHANGIRI, L., P. PUCCI, T. ISHOLA, J. PEREIRA, M.L. CAVANAGH and Suzanne Dawn TURNER. Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors. DISCOVER ONCOLOGY. NEW YORK: SPRINGER, 2021, vol. 12, No 1, p. 56-77. ISSN 1868-8497. Available from: https://dx.doi.org/10.1007/s12672-021-00452-3.
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Basic information
Original name Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors
Authors JAHANGIRI, L., P. PUCCI, T. ISHOLA, J. PEREIRA, M.L. CAVANAGH and Suzanne Dawn TURNER (826 United Kingdom of Great Britain and Northern Ireland, guarantor, belonging to the institution).
Edition DISCOVER ONCOLOGY, NEW YORK, SPRINGER, 2021, 1868-8497.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30204 Oncology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.000
RIV identification code RIV/00216224:14740/21:00124300
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1007/s12672-021-00452-3
UT WoS 000723659800001
Keywords in English Core regulatory circuitry; Neuroblastoma; Solid cancers; Tumour microenvironment; Gene networks; Differentiation
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 18/5/2022 13:41.
Abstract
Aim Neuroblastoma is a heterogeneous childhood cancer derived from the neural crest. The dual cell identities of neuroblastoma include Mesenchymal (MES) and Adrenergic (ADRN). These identities are conferred by a small set of tightly-regulated transcription factors (TFs) binding super enhancers, collectively forming core regulatory circuitries (CRCs). The purpose of this study was to gain a deep understanding of the role of MES and ADRN TFs in neuroblastoma and other cancers as potential indicators of disease prognosis, progression, and relapse. Methods To that end, we first investigated the expression and mutational profile of MES and ADRN TFs in neuroblastoma. Moreover, we established their correlation with neuroblastoma risk groups and overall survival while establishing their extended networks with long non-coding RNAs (lncRNAs). Furthermore, we analysed the pan-cancer expression and mutational profile of these TFs and their correlation with patient survival and finally their network connectivity, using a panel of bioinformatic tools including GEPIA2, human pathology atlas, TIMER2, Omicsnet, and Cytoscape. Results We show the association of multiple MES and ADRN TFs with neuroblastoma risk groups and overall survival and find significantly higher expression of various MES and ADRN TFs compared to normal tissues and their association with overall survival and disease-free survival in multiple cancers. Moreover, we report the strong correlation of the expression of these TFs with the infiltration of stromal and immune cells in the tumour microenvironment and with stemness and metastasis-related genes. Furthermore, we reveal extended pan-cancer networks comprising these TFs that influence the tumour microenvironment and metastasis and may be useful indicators of cancer prognosis and patient survival. Conclusion Our meta-analysis shows the significance of MES and ADRN TFs as indicators of patient prognosis and the putative utility of these TFs as potential novel biomarkers.
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