Analyses of Leishmania-LRV Co-Phylogenetic Patterns and
Evolutionary Variability of Viral Proteins

J 2021

Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins

KOSTYGOV, A.Y., Danyil GRYBCHUK, Y. KLESCHENKO, D.S. CHISTYAKOV, A.N. LUKASHEV et. al.

Basic information

Original name

Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins

Authors

KOSTYGOV, A.Y., Danyil GRYBCHUK (804 Ukraine, guarantor, belonging to the institution), Y. KLESCHENKO, D.S. CHISTYAKOV, A.N. LUKASHEV, E.S. GERASIMOV and V. YURCHENKO

Edition

Viruses-Basel, Basel, Switzerland, MDPI AG, 2021, 1999-4915

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10607 Virology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.818

RIV identification code

RIV/00216224:14740/21:00124308

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3390/v13112305

UT WoS

000727346900001

Keywords in English

Leishmaniavirus; coevolution; phylogenomics

Abstract

V originále

Leishmania spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of Leishmania RNA virus (LRV) confers survival advantage to these parasites by suppressing anti-leishmanial immunity in the vertebrate host. The two viral species, LRV1 and LRV2 infect species of the subgenera Viannia and Leishmania, respectively. In this work we investigated co-phylogenetic patterns of leishmaniae and their viruses on a small scale (LRV2 in L. major) and demonstrated their predominant coevolution, occasionally broken by intraspecific host switches. Our analysis of the two viral genes, encoding the capsid and RNA-dependent RNA polymerase (RDRP), revealed them to be under the pressure of purifying selection, which was considerably stronger for the former gene across the whole tree. The selective pressure also differs between the LRV clades and correlates with the frequency of interspecific host switches. In addition, using experimental (capsid) and predicted (RDRP) models we demonstrated that the evolutionary variability across the structure is strikingly different in these two viral proteins.

Links

LM2018140, research and development project

Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

KOSTYGOV, A.Y., Danyil GRYBCHUK, Y. KLESCHENKO, D.S. CHISTYAKOV, A.N. LUKASHEV, E.S. GERASIMOV and V. YURCHENKO. Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins. Viruses-Basel. Basel, Switzerland: MDPI AG, 2021, vol. 13, No 11, p. 2305-2319. ISSN 1999-4915. Available from: https://dx.doi.org/10.3390/v13112305.

@article{1837295,
   author = {Kostygov, A.Y. and Grybchuk, Danyil and Kleschenko, Y. and Chistyakov, D.S. and Lukashev, A.N. and Gerasimov, E.S. and Yurchenko, V.},
   article_location = {Basel, Switzerland},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/v13112305},
   keywords = {Leishmaniavirus; coevolution; phylogenomics},
   language = {eng},
   issn = {1999-4915},
   journal = {Viruses-Basel},
   title = {Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins},
   url = {https://www.mdpi.com/1999-4915/13/11/2305},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1837295
AU  - Kostygov, A.Y. - Grybchuk, Danyil - Kleschenko, Y. - Chistyakov, D.S. - Lukashev, A.N. - Gerasimov, E.S. - Yurchenko, V.
PY  - 2021
TI  - Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins
JF  - Viruses-Basel
VL  - 13
IS  - 11
SP  - 2305
EP  - 2305
PB  - MDPI AG
SN  - 19994915
KW  - Leishmaniavirus
KW  - coevolution
KW  - phylogenomics
UR  - https://www.mdpi.com/1999-4915/13/11/2305
N2  - Leishmania spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of Leishmania RNA virus (LRV) confers survival advantage to these parasites by suppressing anti-leishmanial immunity in the vertebrate host. The two viral species, LRV1 and LRV2 infect species of the subgenera Viannia and Leishmania, respectively. In this work we investigated co-phylogenetic patterns of leishmaniae and their viruses on a small scale (LRV2 in L. major) and demonstrated their predominant coevolution, occasionally broken by intraspecific host switches. Our analysis of the two viral genes, encoding the capsid and RNA-dependent RNA polymerase (RDRP), revealed them to be under the pressure of purifying selection, which was considerably stronger for the former gene across the whole tree. The selective pressure also differs between the LRV clades and correlates with the frequency of interspecific host switches. In addition, using experimental (capsid) and predicted (RDRP) models we demonstrated that the evolutionary variability across the structure is strikingly different in these two viral proteins.
ER  -

KOSTYGOV, A.Y., Danyil GRYBCHUK, Y. KLESCHENKO, D.S. CHISTYAKOV, A.N. LUKASHEV, E.S. GERASIMOV and V. YURCHENKO. Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins. \textit{Viruses-Basel}. Basel, Switzerland: MDPI AG, 2021, vol.~13, No~11, p.~2305-2319. ISSN~1999-4915. Available from: https://dx.doi.org/10.3390/v13112305.

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