Detailed Information on Publication Record
2022
Instrumental and bioanalytical assessment of pharmaceuticals and hormone-like compounds in a major drinking water source-wastewater receiving Zayandeh Rood river, Iran
DEHKORDI, Shima Kouhi, Hamed PAKNEJAD, Luděk BLÁHA, Helena SVECOVA, Roman GRABIC et. al.Basic information
Original name
Instrumental and bioanalytical assessment of pharmaceuticals and hormone-like compounds in a major drinking water source-wastewater receiving Zayandeh Rood river, Iran
Authors
DEHKORDI, Shima Kouhi (364 Islamic Republic of Iran), Hamed PAKNEJAD (364 Islamic Republic of Iran), Luděk BLÁHA (203 Czech Republic, guarantor, belonging to the institution), Helena SVECOVA (203 Czech Republic), Roman GRABIC (203 Czech Republic), Zdeněk ŠIMEK (203 Czech Republic, belonging to the institution), Alena OTOUPALÍKOVÁ (203 Czech Republic, belonging to the institution) and Michal BITTNER (203 Czech Republic, belonging to the institution)
Edition
Environmental Science and Pollution Research, Heidelberg, Springer Heidelberg, 2022, 0944-1344
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10511 Environmental sciences
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.800
RIV identification code
RIV/00216224:14310/22:00125461
Organization unit
Faculty of Science
UT WoS
000693907600011
Keywords in English
Drugs; Endocrine disruptors; In vitro biotest; LC-MS; MS; Nontargeted screening
Tags
Tags
International impact, Reviewed
Změněno: 3/3/2022 21:03, Mgr. Michaela Hylsová, Ph.D.
Abstract
V originále
Zayandeh Rood river is the most important river in central Iran supplying water for a variety of uses including drinking water for approximately three million inhabitants. The study aimed to investigate the quality of water concerning the presence of pharmaceutical active compounds (PhACs) and hormonelike compounds, which have been only poorly studied in this region. Sampling was performed at seven sites along the river (from headwater sites to downstream drinking water source, corresponding drinking water, and treated wastewater) affected by wastewater effluents, specific drought conditions, and high river-water demand. The targeted and nontargeted chemical analyses and in vitro bioassays were used to evaluate the presence of PhACs and hormonelike compounds in river water. In the samples, 57 PhACs and estrogens were detected with LC-MS/MS with the most common and abundant compounds valsartan, carbamazepine, and caffeine present in the highest concentrations in the treated wastewater in the concentrations of 8.4, 19, and 140 mu g/L, respectively. A battery of in vitro bioassays detected high estrogenicity, androgenicity, and AhR-mediated activity (viz., in treated wastewater) in the concentrations 24.2 ng/L, 62.2 ng/L, and 0.98 ng/L of 17 beta-estradiol, dihydrotestosterone and 2,3,7,8-TCDD equivalents, respectively. In surface water samples, estrogenicity was detected in the range of <0.42 (LOD) to 1.92 ng/L of 17 beta-estradiol equivalents, and the drinking water source contained 0.74 ng/L of 17 beta-estradiol equivalents. About 19% of the estrogenicity could be explained by target chemical analyses, and the remaining estrogenicity can be at least partially attributed to the potentiation effect of detected surfactant residues. Drinking water contained several PhACs and estrogens, but the overall assessment suggested minor human health risk according to the relevant effect-based trigger values. To our knowledge, this study provides some of the first comprehensive information on the levels of PhACs and hormones in Iranian waters.
Links
| EF17_043/0009632, research and development project |
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| LM2018121, research and development project |
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