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@article{1838519,
author = {Nováková, Zuzana and Novák, Jiří and Bittner, Michal and Čupr, Pavel and Přibylová, Petra and Kukučka, Petr and Smutná, Marie and Escher, Beate I. and Demirtepe, Hale and Miralles Marco, Ana Maria and Hilscherová, Klára},
article_location = {Amsterdam},
article_number = {February 2022},
doi = {http://dx.doi.org/10.1016/j.jhazmat.2021.127306},
keywords = {Indoor air; Dust; Endocrine disruption; Bioassay; Mixture},
language = {eng},
issn = {0304-3894},
journal = {Journal of Hazardous Materials},
title = {Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes},
url = {https://www.sciencedirect.com/science/article/pii/S0304389421022743?via%3Dihub},
volume = {424},
year = {2022}
}
TY - JOUR
ID - 1838519
AU - Nováková, Zuzana - Novák, Jiří - Bittner, Michal - Čupr, Pavel - Přibylová, Petra - Kukučka, Petr - Smutná, Marie - Escher, Beate I. - Demirtepe, Hale - Miralles Marco, Ana Maria - Hilscherová, Klára
PY - 2022
TI - Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes
JF - Journal of Hazardous Materials
VL - 424
IS - February 2022
SP - 1-14
EP - 1-14
PB - Elsevier Science BV.
SN - 03043894
KW - Indoor air
KW - Dust
KW - Endocrine disruption
KW - Bioassay
KW - Mixture
UR - https://www.sciencedirect.com/science/article/pii/S0304389421022743?via%3Dihub
N2 - Pollution of indoor environment, where people spend much of their time, comprises complex mixtures of compounds with vastly understudied hazard potential. This study examined several important specific toxic effects and pollutant levels (177 compounds) of indoor samples (air gas phase, PM10 and dust) from different microenvironments after two extractions with focus on their gas/particle/dust distribution and polarity. The endocrine disruptive (ED) potential was assessed by human cell-based in vitro bioassays addressing anti-/ estrogenicity, anti-/androgenicity, aryl hydrocarbon, thyroid and peroxisome proliferator-activated receptormediated activities. Potential toxicity to respiratory tract tissue was assessed using human bronchial cell line. The toxicological analyses pointed out the relevance of both inhalation and ingestion exposure, with significant effects detected after exposure to extracts from all three studied matrices with distinct gas/particle distribution patterns. Chemical analyses document the high complexity of indoor pollutant mixtures with greatest levels of phthalates, their emerging alternatives, and PAHs in dust. Despite the detection of up to 108 chemicals, effects were explained only to low extent. This emphasizes data gaps regarding ED potencies of many detected abundant indoor contaminants, but also potential presence of other unidentified ED compounds. The omnipresent ED potentials in indoor environment rise concern regarding associated human health risk.
ER -
NOVÁKOVÁ, Zuzana, Jiří NOVÁK, Michal BITTNER, Pavel ČUPR, Petra PŘIBYLOVÁ, Petr KUKUČKA, Marie SMUTNÁ, Beate I. ESCHER, Hale DEMIRTEPE, Ana Maria MIRALLES MARCO and Klára HILSCHEROVÁ. Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2022, vol.~424, February 2022, p.~1-14. ISSN~0304-3894. Available from: https://dx.doi.org/10.1016/j.jhazmat.2021.127306.
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