Technology of Processing Plant Extracts Using an
Aluminometasilicate Porous Carrier into a Solid Dosage Form

J 2022

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

KOSTELANSKÁ, Klára, S. KURHAJEC, Sylvie PAVLOKOVÁ, David VETCHÝ, Jan GAJDZIOK et. al.

Basic information

Original name

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

Authors

KOSTELANSKÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), S. KURHAJEC, Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution), David VETCHÝ (203 Czech Republic, belonging to the institution), Jan GAJDZIOK (203 Czech Republic, belonging to the institution) and Aleš FRANC (203 Czech Republic, belonging to the institution)

Edition

Pharmaceutics, Basel, MDPI, 2022, 1999-4923

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.400

RIV identification code

RIV/00216224:14160/22:00125492

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/pharmaceutics14020248

UT WoS

000764616000001

Keywords in English

Adsorption; Antioxidant activity; Liquisolid systems; Magnesium aluminometasilicates; Plant extracts; Porous carriers

Abstract

V originále

A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium aluminometasilicates, silica aerogels, mesoporous silicates, clays, etc. In this study, magnesium aluminometasilicate is used to prepare modified LSS formulations with plant extracts as model drugs dissolved in water (W) or ethanol (E). The modification involves drying tablets in a microwave (MW) and hot air dryer (HA) for a specified period. Powder blends and tablets were evaluated for physical properties, and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). PLS and ANOVA were used to compare tablets properties depending on the composition and technology. The experiment is based on a previous one, in which the plant extracts were processed into tablets using a similar method. Therefore, extending the study to include more plants and the robust statistical evaluation and comparison of the products was a procedure to justify the suitability of the presented method for a wide range of liquid plant extracts. As a result, we obtained tablets with excellent physical properties, including a short disintegration and dissolution, which is problematic in tableted extracts.

Citovat

KOSTELANSKÁ, Klára, S. KURHAJEC, Sylvie PAVLOKOVÁ, David VETCHÝ, Jan GAJDZIOK and Aleš FRANC. Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form. Pharmaceutics. Basel: MDPI, 2022, vol. 14, No 2, p. 1-20. ISSN 1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics14020248.

@article{1839859,
   author = {Kostelanská, Klára and Kurhajec, S. and Pavloková, Sylvie and Vetchý, David and Gajdziok, Jan and Franc, Aleš},
   article_location = {Basel},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/pharmaceutics14020248},
   keywords = {Adsorption; Antioxidant activity; Liquisolid systems; Magnesium aluminometasilicates; Plant extracts; Porous carriers},
   language = {eng},
   issn = {1999-4923},
   journal = {Pharmaceutics},
   title = {Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form},
   url = {https://www.mdpi.com/1999-4923/14/2/248},
   volume = {14},
   year = {2022}
}

TY  - JOUR
ID  - 1839859
AU  - Kostelanská, Klára - Kurhajec, S. - Pavloková, Sylvie - Vetchý, David - Gajdziok, Jan - Franc, Aleš
PY  - 2022
TI  - Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form
JF  - Pharmaceutics
VL  - 14
IS  - 2
SP  - 1-20
EP  - 1-20
PB  - MDPI
SN  - 19994923
KW  - Adsorption
KW  - Antioxidant activity
KW  - Liquisolid systems
KW  - Magnesium aluminometasilicates
KW  - Plant extracts
KW  - Porous carriers
UR  - https://www.mdpi.com/1999-4923/14/2/248
N2  - A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium aluminometasilicates, silica aerogels, mesoporous silicates, clays, etc. In this study, magnesium aluminometasilicate is used to prepare modified LSS formulations with plant extracts as model drugs dissolved in water (W) or ethanol (E). The modification involves drying tablets in a microwave (MW) and hot air dryer (HA) for a specified period. Powder blends and tablets were evaluated for physical properties, and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). PLS and ANOVA were used to compare tablets properties depending on the composition and technology. The experiment is based on a previous one, in which the plant extracts were processed into tablets using a similar method. Therefore, extending the study to include more plants and the robust statistical evaluation and comparison of the products was a procedure to justify the suitability of the presented method for a wide range of liquid plant extracts. As a result, we obtained tablets with excellent physical properties, including a short disintegration and dissolution, which is problematic in tableted extracts.
ER  -

KOSTELANSKÁ, Klára, S. KURHAJEC, Sylvie PAVLOKOVÁ, David VETCHÝ, Jan GAJDZIOK and Aleš FRANC. Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form. \textit{Pharmaceutics}. Basel: MDPI, 2022, vol.~14, No~2, p.~1-20. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics14020248.

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