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@proceedings{1839977, author = {Goněc, Tomáš and Oravec, Michal and Jampílek, Josef}, doi = {http://dx.doi.org/10.3390/ecsoc-25-11652}, keywords = {Hydroxynaphthalene-carboxamides; PET inhibition; Spinach chloroplasts}, language = {eng}, title = {Photosynthesis-Inhibiting Activity of Fluorinated 2‑Hydroxynaphthalene-1-carboxanilides}, url = {https://sciforum.net/paper/view/11652}, year = {2021} }
TY - CONF ID - 1839977 AU - Goněc, Tomáš - Oravec, Michal - Jampílek, Josef PY - 2021 TI - Photosynthesis-Inhibiting Activity of Fluorinated 2‑Hydroxynaphthalene-1-carboxanilides KW - Hydroxynaphthalene-carboxamides KW - PET inhibition KW - Spinach chloroplasts UR - https://sciforum.net/paper/view/11652 N2 - 2-Hydroxy-N-phenylnaphthalene-1-carboxamide, three fluoro monosubstituted and five fluoro disubstituted 2-hydroxynaphthalene-1-carboxanilides were prepared by microwave-assisted synthesis and characterized. All the compounds were evaluated for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET inhibitory activity of the discussed compounds proved to be in a wide range, from inactive N-(2,6-difluorophenyl)-2-hydroxynaphthalene-1-carboxamide with an IC50 = 904 μM to N-(2,5-difluorophenyl)-2-hydroxynaphthalene-1-carboxamide with an IC50 of 44.2 μM, which was the most potent isomer of the series of evaluated compounds. Based on previous studies, it can be assumed that the mechanism of PET inhibition of these compounds is the inhibition of photosystem II in the thylakoid membrane. ER -
GONĚC, Tomáš, Michal ORAVEC a Josef JAMPÍLEK. \textit{Photosynthesis-Inhibiting Activity of Fluorinated 2‑Hydroxynaphthalene-1-carboxanilides}. 2021. Dostupné z: https://dx.doi.org/10.3390/ecsoc-25-11652.
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