GONĚC, Tomáš, Michal ORAVEC and Josef JAMPÍLEK. Photosynthesis-Inhibiting Activity of Fluorinated 2‑Hydroxynaphthalene-1-carboxanilides. 2021. Available from: https://dx.doi.org/10.3390/ecsoc-25-11652.
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Basic information
Original name Photosynthesis-Inhibiting Activity of Fluorinated 2‑Hydroxynaphthalene-1-carboxanilides
Name in Czech Fluorované 2-hydroxynaftalen-1-karboxanilidy inhibující fotosyntézu
Authors GONĚC, Tomáš, Michal ORAVEC and Josef JAMPÍLEK.
Edition 2021.
Other information
Original language English
Type of outcome Conference abstract
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization unit Faculty of Pharmacy
Doi http://dx.doi.org/10.3390/ecsoc-25-11652
Keywords (in Czech) hydroxynaftalenkarboxamid; inhibice PET; chloroplasty špenátu
Keywords in English Hydroxynaphthalene-carboxamides; PET inhibition; Spinach chloroplasts
Tags International impact, Reviewed
Changed by Changed by: PharmDr. Tomáš Goněc, Ph.D., učo 39112. Changed: 11/3/2022 16:03.
Abstract
2-Hydroxy-N-phenylnaphthalene-1-carboxamide, three fluoro monosubstituted and five fluoro disubstituted 2-hydroxynaphthalene-1-carboxanilides were prepared by microwave-assisted synthesis and characterized. All the compounds were evaluated for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET inhibitory activity of the discussed compounds proved to be in a wide range, from inactive N-(2,6-difluorophenyl)-2-hydroxynaphthalene-1-carboxamide with an IC50 = 904 μM to N-(2,5-difluorophenyl)-2-hydroxynaphthalene-1-carboxamide with an IC50 of 44.2 μM, which was the most potent isomer of the series of evaluated compounds. Based on previous studies, it can be assumed that the mechanism of PET inhibition of these compounds is the inhibition of photosystem II in the thylakoid membrane.
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