| MINERVINA, A.A., E.A. KOMECH, A. TITOV, M.B. KORAICHI, E. ROSATI, Ilgar MAMEDOV, A. FRANKE, G.A. EFIMOV, Dmitriy CHUDAKOV, T. MORA, A.M. WALCZAK, Y.B. LEBEDEV and M.V. POGORELYY. Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection. elife. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, 2021, vol. 10, JAN, p. 1-17. ISSN 2050-084X. Available from: https://dx.doi.org/10.7554/eLife.63502. |
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@article{1840782,
author = {Minervina, A.A. and Komech, E.A. and Titov, A. and Koraichi, M.B. and Rosati, E. and Mamedov, Ilgar and Franke, A. and Efimov, G.A. and Chudakov, Dmitriy and Mora, T. and Walczak, A.M. and Lebedev, Y.B. and Pogorelyy, M.V.},
article_location = {CAMBRIDGE},
article_number = {JAN},
doi = {http://dx.doi.org/10.7554/eLife.63502},
keywords = {Amino Acid Sequence; COVID-19; Cross Reactions; Epitope Mapping},
language = {eng},
issn = {2050-084X},
journal = {elife},
title = {Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection},
url = {https://elifesciences.org/articles/63502},
volume = {10},
year = {2021}
}
TY - JOUR
ID - 1840782
AU - Minervina, A.A. - Komech, E.A. - Titov, A. - Koraichi, M.B. - Rosati, E. - Mamedov, Ilgar - Franke, A. - Efimov, G.A. - Chudakov, Dmitriy - Mora, T. - Walczak, A.M. - Lebedev, Y.B. - Pogorelyy, M.V.
PY - 2021
TI - Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection
JF - elife
VL - 10
IS - JAN
SP - 1-17
EP - 1-17
PB - ELIFE SCIENCES PUBLICATIONS LTD
SN - 2050084X
KW - Amino Acid Sequence
KW - COVID-19
KW - Cross Reactions
KW - Epitope Mapping
UR - https://elifesciences.org/articles/63502
N2 - COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells and facilitating the selection of virus-specific antibodies. However, neither the dynamics and cross-reactivity of the SARS-CoV-2-specific T-cell response nor the diversity of resulting immune memory is well understood. In this study, we use longitudinal high-throughput T-cell receptor (TCR) sequencing to track changes in the T-cell repertoire following two mild cases of COVID-19. In both donors, we identified CD4(+) and CD8(+) T-cell clones with transient clonal expansion after infection. We describe characteristic motifs in TCR sequences of COVID-19-reactive clones and show preferential occurrence of these motifs in publicly available large dataset of repertoires from COVID-19 patients. We show that in both donors, the majority of infection-reactive clonotypes acquire memory phenotypes. Certain T-cell clones were detected in the memory fraction at the preinfection time point, suggesting participation of pre-existing cross-reactive memory T cells in the immune response to SARS-CoV-2.
ER -
MINERVINA, A.A., E.A. KOMECH, A. TITOV, M.B. KORAICHI, E. ROSATI, Ilgar MAMEDOV, A. FRANKE, G.A. EFIMOV, Dmitriy CHUDAKOV, T. MORA, A.M. WALCZAK, Y.B. LEBEDEV and M.V. POGORELYY. Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection. \textit{elife}. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, 2021, vol.~10, JAN, p.~1-17. ISSN~2050-084X. Available from: https://dx.doi.org/10.7554/eLife.63502.
|
