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@article{1841317,
author = {Holická, Martina and Muselík, Jan and Kejdušová, Martina and Pavelková, Miroslava and Kubová, Kateřina and Doležel, Petr and Vetchý, David and Košťál, Vratislav and Vysloužil, Jakub and Mašek, Josef},
article_number = {6},
keywords = {microparticles; mirtazapine; multivariate data analysis; PLGA; solvent evaporation method},
language = {eng},
issn = {1210-7816},
journal = {Česká a slovenská farmacie},
title = {Preformulation design of PLGA particulate system for multi-day drug delivery of the antidepressant mirtazapine},
url = {https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-6-12/preformulacni-design-plga-casticoveho-systemu-pro-vicedenni-uvolnovani-antidepresiva-mirtazapinu-129704/download?hl=cs},
volume = {70},
year = {2021}
}
TY - JOUR
ID - 1841317
AU - Holická, Martina - Muselík, Jan - Kejdušová, Martina - Pavelková, Miroslava - Kubová, Kateřina - Doležel, Petr - Vetchý, David - Košťál, Vratislav - Vysloužil, Jakub - Mašek, Josef
PY - 2021
TI - Preformulation design of PLGA particulate system for multi-day drug delivery of the antidepressant mirtazapine
JF - Česká a slovenská farmacie
VL - 70
IS - 6
SP - 210-219
EP - 210-219
PB - Česká lékařská společnost J.E. Purkyně
SN - 12107816
KW - microparticles
KW - mirtazapine
KW - multivariate data analysis
KW - PLGA
KW - solvent evaporation method
UR - https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-6-12/preformulacni-design-plga-casticoveho-systemu-pro-vicedenni-uvolnovani-antidepresiva-mirtazapinu-129704/download?hl=cs
N2 - In this experimental study, the biodegradable polylactide-co-glycolide (PLGA) microparticles (MP) loaded with the insoluble antidepressant mirtazapine were prepared by the simple o/w solvent evaporation method. The formation involved intrinsic variables, such as the content of polymer (700, 900 or 1200 mg), dichloromethane (5 or 10 ml) and/or drug (200 or 400 or 600 mg), and the volume of the aqueous emulsion phase (400, 600 or 800 ml). The influence of these parameters on the size and morphology of microparticles, encapsulation efficiency, and drug release behavior was observed. All MP were successfully prepared, and their size ranged between 165.34 ± 42.88 and 360.17 ± 121.59 μm. MP exhibited prolonged drug release (days), and some profiles had multiphasic character. It was found that the samples prepared with a higher initial amount of PLGA were bigger with prolonged lag time up to 34.3 hours. On the other hand, higher drug concentrations reduced the lag time. The external phase volume reduction and multiplication of dichloromethane amount prolonged the mirtazapine release and decreased the encapsulation efficiency. These observations were further confirmed by multivariate data analysis.
ER -
HOLICKÁ, Martina, Jan MUSELÍK, Martina KEJDUŠOVÁ, Miroslava PAVELKOVÁ, Kateřina KUBOVÁ, Petr DOLEŽEL, David VETCHÝ, Vratislav KOŠŤÁL, Jakub VYSLOUŽIL and Josef MAŠEK. Preformulation design of PLGA particulate system for multi-day drug delivery of the antidepressant mirtazapine (Preformulační design PLGA částicového systému pro vícedenní uvolňování antidepresiva mirtazapinu). \textit{Česká a slovenská farmacie}. Česká lékařská společnost J.E. Purkyně, 2021, vol.~70, No~6, p.~210-219. ISSN~1210-7816.
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