PARUCH, Kamil, Benoit Jean-Pierre CARBAIN, Štěpán HAVEL, Jiří DAMBORSKÝ, Jan BREZOVSKÝ, Lukáš DANIEL, Alexandra SISÁKOVÁ, Fedor NIKULENKOV and Lumír KREJČÍ. SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES. 2021.
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Basic information
Original name SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES
Authors PARUCH, Kamil (203 Czech Republic, belonging to the institution), Benoit Jean-Pierre CARBAIN (250 France, belonging to the institution), Štěpán HAVEL (203 Czech Republic, belonging to the institution), Jiří DAMBORSKÝ (203 Czech Republic, belonging to the institution), Jan BREZOVSKÝ (203 Czech Republic, belonging to the institution), Lukáš DANIEL (203 Czech Republic, belonging to the institution), Alexandra SISÁKOVÁ (703 Slovakia, belonging to the institution), Fedor NIKULENKOV (203 Czech Republic, belonging to the institution) and Lumír KREJČÍ (203 Czech Republic, belonging to the institution).
Edition Number: EP3556755B1, Publisher: European Patent Office, Place of publication: Mnichov, Owner's name: Masarykova Univerzita, 2021.
Other information
Original language English
Type of outcome Patent
Field of Study 10401 Organic chemistry
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14310/21:00124423
Organization unit Faculty of Science
Keywords in English Antineoplastic agents; not condensed and containing further heterocyclic rings; condensed with carbocyclic rings; directly linked by a ring-member-to-ring-member bond; linked by a chain containing hetero atoms as chain links
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 23/3/2022 09:59.
Abstract
The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
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