| MAZANEC, H., P. KONIK, Z. GARDIAN a R. KUCHTA. Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition. International Journal for Parasitology. Oxford: Elsevier Science Ltd., 2021, roč. 51, č. 5, s. 327-332. ISSN 0020-7519. Dostupné z: https://dx.doi.org/10.1016/j.ijpara.2020.09.010. |
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@article{1842613,
author = {Mazanec, H. and Konik, P. and Gardian, Z. and Kuchta, R.},
article_location = {Oxford},
article_number = {5},
doi = {http://dx.doi.org/10.1016/j.ijpara.2020.09.010},
keywords = {Exosomes; Secretion; Proteins; Size exclusion chromatography; LC?MS; MS; Electron microscopy},
language = {eng},
issn = {0020-7519},
journal = {International Journal for Parasitology},
title = {Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition},
url = {https://www.sciencedirect.com/science/article/pii/S0020751920303179?via%3Dihub},
volume = {51},
year = {2021}
}
TY - JOUR
ID - 1842613
AU - Mazanec, H. - Konik, P. - Gardian, Z. - Kuchta, R.
PY - 2021
TI - Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition
JF - International Journal for Parasitology
VL - 51
IS - 5
SP - 327-332
EP - 327-332
PB - Elsevier Science Ltd.
SN - 00207519
KW - Exosomes
KW - Secretion
KW - Proteins
KW - Size exclusion chromatography
KW - LC?MS
KW - MS
KW - Electron microscopy
UR - https://www.sciencedirect.com/science/article/pii/S0020751920303179?via%3Dihub
N2 - We provided the first known evidence of the presence and release of extracellular vesicles in adults of important model tapeworm Hymenolepis diminuta. Two different subtypes have been observed on the surface of the worm and among the secretory products confirmed by several microscopical methods. Proteomic analysis revealed the presence of parasite-specific proteins as well as those of the host in purified extracellular vesicles. Among the protein cargo, we identified potential drug targets, vaccine candidates and H. diminuta antigens. Finally, the protein composition further revealed proteins participating in the endosomal complex required for transport-dependent biogenesis pathway. (c)& nbsp;2020 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.
ER -
MAZANEC, H., P. KONIK, Z. GARDIAN a R. KUCHTA. Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition. \textit{International Journal for Parasitology}. Oxford: Elsevier Science Ltd., 2021, roč.~51, č.~5, s.~327-332. ISSN~0020-7519. Dostupné z: https://dx.doi.org/10.1016/j.ijpara.2020.09.010.
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