Socioeconomic deprivation in early life and symptoms of
depression and anxiety in young adulthood: Mediating role of
hippocampal connectivity

J 2022

Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity

ČERMÁKOVÁ, P., Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Klára MAREČKOVÁ

Basic information

Original name

Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity

Authors

ČERMÁKOVÁ, P., Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Klára MAREČKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Psychological Medicine, Velká Británie, Cambridge University Press, 2022, 0033-2917

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.900

RIV identification code

RIV/00216224:14740/22:00125564

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1017/S0033291720004754

UT WoS

000880310400031

Keywords in English

anxiety; depression; fMRI; sex differences

Abstract

V originále

Background Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. Methods We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected via questionnaire from mothers during the first 18 months of participants' lives. At age 23-24, participants underwent examination by structural magnetic resonance imaging, resting-state functional connectivity and assessment of depressive symptoms (Mood and Feelings Questionnaire) and anxiety (Spielberger State-Trait Anxiety Inventory). The association of ELSD with brain outcomes in young adulthood was assessed with correlations, linear regression (adjusting for sex, socioeconomic position and mother's mental health) and moderated mediation analysis. Results Higher ELSD was associated with greater depressive symptoms (B = 0.22; p = 0.001), trait anxiety (B = 0.07; p = 0.02) and lower global connectivity of the right hippocampus (B =-0.01; p = 0.02). These associations persisted when adjusted for covariates. In women, lower global connectivity of the right hippocampus was associated with stronger trait anxiety (B =-4.14; p = 0.01). Global connectivity of the right hippocampus as well as connectivity between the right hippocampus and the left middle temporal gyrus mediated the association between ELSD and trait anxiety in women. Higher ELSD correlated with a lower volume of the right hippocampus in men, but the volume of the right hippocampus was not related to mental health. Conclusions Early preventive strategies targeted at children from socioeconomically deprived families may yield long-lasting benefits for the mental health of the population. © 2020 The Author(s). Published by Cambridge University Press.

Links

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

90062, large research infrastructures

Name: Czech-BioImaging

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

ČERMÁKOVÁ, P., Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Klára MAREČKOVÁ. Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity. Psychological Medicine. Velká Británie: Cambridge University Press, 2022, vol. 52, No 13, p. 2671-2680. ISSN 0033-2917. Available from: https://dx.doi.org/10.1017/S0033291720004754.

@article{1842657,
   author = {Čermáková, P. and Andrýsková, Lenka and Brázdil, Milan and Marečková, Klára},
   article_location = {Velká Británie},
   article_number = {13},
   doi = {http://dx.doi.org/10.1017/S0033291720004754},
   keywords = {anxiety; depression; fMRI; sex differences},
   language = {eng},
   issn = {0033-2917},
   journal = {Psychological Medicine},
   title = {Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity},
   url = {https://www.cambridge.org/core/journals/psychological-medicine/article/socioeconomic-deprivation-in-early-life-and-symptoms-of-depression-and-anxiety-in-young-adulthood-mediating-role-of-hippocampal-connectivity/389D84B5689593935017EA38FA905E44},
   volume = {52},
   year = {2022}
}

TY  - JOUR
ID  - 1842657
AU  - Čermáková, P. - Andrýsková, Lenka - Brázdil, Milan - Marečková, Klára
PY  - 2022
TI  - Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity
JF  - Psychological Medicine
VL  - 52
IS  - 13
SP  - 2671-2680
EP  - 2671-2680
PB  - Cambridge University Press
SN  - 00332917
KW  - anxiety
KW  - depression
KW  - fMRI
KW  - sex differences
UR  - https://www.cambridge.org/core/journals/psychological-medicine/article/socioeconomic-deprivation-in-early-life-and-symptoms-of-depression-and-anxiety-in-young-adulthood-mediating-role-of-hippocampal-connectivity/389D84B5689593935017EA38FA905E44
N2  - Background Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. Methods We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected via questionnaire from mothers during the first 18 months of participants' lives. At age 23-24, participants underwent examination by structural magnetic resonance imaging, resting-state functional connectivity and assessment of depressive symptoms (Mood and Feelings Questionnaire) and anxiety (Spielberger State-Trait Anxiety Inventory). The association of ELSD with brain outcomes in young adulthood was assessed with correlations, linear regression (adjusting for sex, socioeconomic position and mother's mental health) and moderated mediation analysis. Results Higher ELSD was associated with greater depressive symptoms (B = 0.22; p = 0.001), trait anxiety (B = 0.07; p = 0.02) and lower global connectivity of the right hippocampus (B =-0.01; p = 0.02). These associations persisted when adjusted for covariates. In women, lower global connectivity of the right hippocampus was associated with stronger trait anxiety (B =-4.14; p = 0.01). Global connectivity of the right hippocampus as well as connectivity between the right hippocampus and the left middle temporal gyrus mediated the association between ELSD and trait anxiety in women. Higher ELSD correlated with a lower volume of the right hippocampus in men, but the volume of the right hippocampus was not related to mental health. Conclusions Early preventive strategies targeted at children from socioeconomically deprived families may yield long-lasting benefits for the mental health of the population. © 2020 The Author(s). Published by Cambridge University Press.
ER  -

ČERMÁKOVÁ, P., Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Klára MAREČKOVÁ. Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity. \textit{Psychological Medicine}. Velká Británie: Cambridge University Press, 2022, vol.~52, No~13, p.~2671-2680. ISSN~0033-2917. Available from: https://dx.doi.org/10.1017/S0033291720004754.

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