| DAVE, Zankruti, Olga VONDÁLOVÁ BLANÁŘOVÁ, Štěpán ČADA, Pavlína JANOVSKÁ, Nikodém ZEZULA, Martin BĚHAL, Kateřina HANÁKOVÁ, Sri Ranjani GANJI, Pavel KREJČÍ, Kristína GÖMÖRYOVÁ, Helena PESCHELOVÁ, Michal ŠMÍDA, Zbyněk ZDRÁHAL, Šárka PAVLOVÁ, Jana KOTAŠKOVÁ, Šárka POSPÍŠILOVÁ and Vítězslav BRYJA. Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells. Frontiers in Cell and Developmental Biology. Frontiers Media SA, 2022, vol. 10, February 2022, p. 1-11. ISSN 2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2022.838871. |
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@article{1843559,
author = {Dave, Zankruti and Vondálová Blanářová, Olga and Čada, Štěpán and Janovská, Pavlína and Zezula, Nikodém and Běhal, Martin and Hanáková, Kateřina and Ganji, Sri Ranjani and Krejčí, Pavel and Gömöryová, Kristína and Peschelová, Helena and Šmída, Michal and Zdráhal, Zbyněk and Pavlová, Šárka and Kotašková, Jana and Pospíšilová, Šárka and Bryja, Vítězslav},
article_number = {February 2022},
doi = {http://dx.doi.org/10.3389/fcell.2022.838871},
keywords = {Ror1; Lyn; crosstalk; phosphorylation; CLL; BCR; signaling pathway},
language = {eng},
issn = {2296-634X},
journal = {Frontiers in Cell and Developmental Biology},
title = {Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells},
url = {https://www.frontiersin.org/articles/10.3389/fcell.2022.838871/full},
volume = {10},
year = {2022}
}
TY - JOUR
ID - 1843559
AU - Dave, Zankruti - Vondálová Blanářová, Olga - Čada, Štěpán - Janovská, Pavlína - Zezula, Nikodém - Běhal, Martin - Hanáková, Kateřina - Ganji, Sri Ranjani - Krejčí, Pavel - Gömöryová, Kristína - Peschelová, Helena - Šmída, Michal - Zdráhal, Zbyněk - Pavlová, Šárka - Kotašková, Jana - Pospíšilová, Šárka - Bryja, Vítězslav
PY - 2022
TI - Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
JF - Frontiers in Cell and Developmental Biology
VL - 10
IS - February 2022
SP - 1-11
EP - 1-11
PB - Frontiers Media SA
SN - 2296634X
KW - Ror1
KW - Lyn
KW - crosstalk
KW - phosphorylation
KW - CLL
KW - BCR
KW - signaling pathway
UR - https://www.frontiersin.org/articles/10.3389/fcell.2022.838871/full
N2 - Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic targets in these diseases and the understanding of their mutual cross talk is thus of direct therapeutic relevance. In this study we analyzed the role of Lyn, a kinase from the Src family participating in BCR signaling, as a mediator of the BCR-ROR1 crosstalk. We confirm the functional interaction between Lyn and ROR1 and demonstrate that Lyn kinase efficiently phosphorylates ROR1 in its kinase domain and aids the recruitment of the E3 ligase c-CBL. We show that ROR1 surface dynamics in migrating primary CLL cells as well as chemotactic properties of CLL cells were inhibited by Lyn inhibitor dasatinib. Our data establish Lyn-mediated phosphorylation of ROR1 as a point of crosstalk between BCR and ROR1 signaling pathways.
ER -
DAVE, Zankruti, Olga VONDÁLOVÁ BLANÁŘOVÁ, Štěpán ČADA, Pavlína JANOVSKÁ, Nikodém ZEZULA, Martin BĚHAL, Kateřina HANÁKOVÁ, Sri Ranjani GANJI, Pavel KREJČÍ, Kristína GÖMÖRYOVÁ, Helena PESCHELOVÁ, Michal ŠMÍDA, Zbyněk ZDRÁHAL, Šárka PAVLOVÁ, Jana KOTAŠKOVÁ, Šárka POSPÍŠILOVÁ and Vítězslav BRYJA. Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells. \textit{Frontiers in Cell and Developmental Biology}. Frontiers Media SA, 2022, vol.~10, February 2022, p.~1-11. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2022.838871.
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