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@article{1843917,
author = {Ťapuchová, Ivana and Pytlik, Robert and Šimara, Pavel and Tesařová, Lenka and Koutná, Irena},
article_location = {Amsterdam},
article_number = {April},
doi = {http://dx.doi.org/10.1016/j.trim.2022.101539},
keywords = {Virus-specific T cells; Herpesviruses; Adoptive transfer; Cytomegalovirus; Resistance; Interferon gamma; Immunotherapy},
language = {eng},
issn = {0966-3274},
journal = {Transplant Immunology},
title = {Cytomegalovirus and other herpesviruses after hematopoietic cell and solid organ transplantation: From antiviral drugs to virus-specific T cells},
url = {https://www.sciencedirect.com/science/article/pii/S0966327422000132},
volume = {71},
year = {2022}
}
TY - JOUR
ID - 1843917
AU - Ťapuchová, Ivana - Pytlik, Robert - Šimara, Pavel - Tesařová, Lenka - Koutná, Irena
PY - 2022
TI - Cytomegalovirus and other herpesviruses after hematopoietic cell and solid organ transplantation: From antiviral drugs to virus-specific T cells
JF - Transplant Immunology
VL - 71
IS - April
SP - 1-13
EP - 1-13
PB - Elsevier B.V.
SN - 09663274
KW - Virus-specific T cells
KW - Herpesviruses
KW - Adoptive transfer
KW - Cytomegalovirus
KW - Resistance
KW - Interferon gamma
KW - Immunotherapy
UR - https://www.sciencedirect.com/science/article/pii/S0966327422000132
N2 - Herpesviruses can either cause primary infection or may get reactivated after both hematopoietic cell and solid organ transplantations. In general, viral infections increase post-transplant morbidity and mortality. Prophylactic, preemptive, or therapeutically administered antiviral drugs may be associated with serious side effects and may induce viral resistance. Virus-specific T cells represent a valuable addition to antiviral treatment, with high rates of response and minimal side effects. Even low numbers of virus-specific T cells manufactured by direct selection methods can reconstitute virus-specific immunity after transplantation and control viral replication. Virus-specific T cells belong to the advanced therapy medicinal products, and their production is regulated by appropriate legislation; also, strict safety regulations are required to minimize their side effects.
ER -
ŤAPUCHOVÁ, Ivana, Robert PYTLIK, Pavel ŠIMARA, Lenka TESAŘOVÁ and Irena KOUTNÁ. Cytomegalovirus and other herpesviruses after hematopoietic cell and solid organ transplantation: From antiviral drugs to virus-specific T cells. \textit{Transplant Immunology}. Amsterdam: Elsevier B.V., 2022, vol.~71, April, p.~1-13. ISSN~0966-3274. Available from: https://dx.doi.org/10.1016/j.trim.2022.101539.
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