Impact of Prenatal Stress on Amygdala Anatomy in Young
Adulthood: Timing and Location Matter

J 2022

Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter

MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, Y.S. NIKOLOVA et. al.

Basic information

Original name

Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter

Authors

MAREČKOVÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Y.S. NIKOLOVA

Edition

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2022, 2451-9022

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.900

RIV identification code

RIV/00216224:14740/22:00125608

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.bpsc.2021.07.009

UT WoS

000753182800015

Keywords in English

MATERNAL DEPRESSIVE SYMPTOMSNEUROBIOLOGICAL CONSEQUENCESFUNCTIONAL CONNECTIVITYBASOLATERAL AMYGDALABRAIN-DEVELOPMENTCORTICAL NUCLEUSHIPPOCAMPUSSYSTEMVOLUMEAGE

Abstract

V originále

BACKGROUND: Exposure to maternal stress in utero has long-term implications for the developing brain and has been linked with a higher risk of depression. The amygdala, which develops during the early embryonic stage and is critical for emotion processing, might be particularly sensitive. METHODS: Using data from a neuroimaging follow-up of the European Longitudinal Study of Pregnancy and Childhood prenatal birth cohort (n = 129, 47% men, 23-24 years old), we studied the impact of prenatal stress during the first and second halves of pregnancy on the volume of the amygdala and its nuclei in young adult offspring. We further evaluated the relationship between amygdala anatomy and offspring depressive symptomatology. Amygdala nuclei were parcellated using FreeSurfer's automated segmentation pipeline. Depressive symptoms were measured via self-report using the Beck Depression Inventory. RESULTS: Exposure to stress during the first half of pregnancy was associated with smaller accessory basal (Cohen's f(2) = 0.27, false discovery rate [FDR]-corrected p [pFDR] = .03) and cortical (Cohen's f(2) = 0.29, pFDR = .03) nuclei volumes. This effect remained significant after correcting for sex, stress during the second half of pregnancy, maternal age at birth, birth weight, maternal education, and offspring's age at magnetic resonance imaging. These two nuclei showed a quadratic relationship with Beck Depression Inventory scores in young adulthood, where both smaller and larger volumes were associated with more depressive symptoms (accessory basal nucleus: adj. R-2 = 0.05, pFDR = .015; cortical nucleus: adj. R-2 = 0.04, pFDR = .015). CONCLUSIONS: We conclude that exposure to stress during the first half of pregnancy might have long-term implications for amygdala anatomy, which may in turn predict the experience of depressive symptoms in young adulthood.

Links

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NU20J-04-00022, research and development project

Name: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministry of Health of the CR, Healthy Brain Ageing in Czechia over the life-course, Subprogram 2 - junior

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Y.S. NIKOLOVA. Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter. BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 2022, vol. 7, No 2, p. 231-238. ISSN 2451-9022. Available from: https://dx.doi.org/10.1016/j.bpsc.2021.07.009.

@article{1844917,
   author = {Marečková, Klára and Mareček, Radek and Andrýsková, Lenka and Brázdil, Milan and Nikolova, Y.S.},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.bpsc.2021.07.009},
   keywords = {MATERNAL DEPRESSIVE SYMPTOMSNEUROBIOLOGICAL CONSEQUENCESFUNCTIONAL CONNECTIVITYBASOLATERAL AMYGDALABRAIN-DEVELOPMENTCORTICAL NUCLEUSHIPPOCAMPUSSYSTEMVOLUMEAGE},
   language = {eng},
   issn = {2451-9022},
   journal = {BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING},
   title = {Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter},
   url = {https://www.sciencedirect.com/science/article/pii/S2451902221002032?via%3Dihub},
   volume = {7},
   year = {2022}
}

TY  - JOUR
ID  - 1844917
AU  - Marečková, Klára - Mareček, Radek - Andrýsková, Lenka - Brázdil, Milan - Nikolova, Y.S.
PY  - 2022
TI  - Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter
JF  - BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
VL  - 7
IS  - 2
SP  - 231-238
EP  - 231-238
SN  - 24519022
KW  - MATERNAL DEPRESSIVE SYMPTOMSNEUROBIOLOGICAL CONSEQUENCESFUNCTIONAL CONNECTIVITYBASOLATERAL AMYGDALABRAIN-DEVELOPMENTCORTICAL NUCLEUSHIPPOCAMPUSSYSTEMVOLUMEAGE
UR  - https://www.sciencedirect.com/science/article/pii/S2451902221002032?via%3Dihub
N2  - BACKGROUND: Exposure to maternal stress in utero has long-term implications for the developing brain and has been linked with a higher risk of depression. The amygdala, which develops during the early embryonic stage and is critical for emotion processing, might be particularly sensitive. METHODS: Using data from a neuroimaging follow-up of the European Longitudinal Study of Pregnancy and Childhood prenatal birth cohort (n = 129, 47% men, 23-24 years old), we studied the impact of prenatal stress during the first and second halves of pregnancy on the volume of the amygdala and its nuclei in young adult offspring. We further evaluated the relationship between amygdala anatomy and offspring depressive symptomatology. Amygdala nuclei were parcellated using FreeSurfer's automated segmentation pipeline. Depressive symptoms were measured via self-report using the Beck Depression Inventory. RESULTS: Exposure to stress during the first half of pregnancy was associated with smaller accessory basal (Cohen's f(2) = 0.27, false discovery rate [FDR]-corrected p [pFDR] = .03) and cortical (Cohen's f(2) = 0.29, pFDR = .03) nuclei volumes. This effect remained significant after correcting for sex, stress during the second half of pregnancy, maternal age at birth, birth weight, maternal education, and offspring's age at magnetic resonance imaging. These two nuclei showed a quadratic relationship with Beck Depression Inventory scores in young adulthood, where both smaller and larger volumes were associated with more depressive symptoms (accessory basal nucleus: adj. R-2 = 0.05, pFDR = .015; cortical nucleus: adj. R-2 = 0.04, pFDR = .015). CONCLUSIONS: We conclude that exposure to stress during the first half of pregnancy might have long-term implications for amygdala anatomy, which may in turn predict the experience of depressive symptoms in young adulthood.
ER  -

MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Y.S. NIKOLOVA. Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter. \textit{BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING}. 2022, vol.~7, No~2, p.~231-238. ISSN~2451-9022. Available from: https://dx.doi.org/10.1016/j.bpsc.2021.07.009.

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