Detailed Information on Publication Record
2022
Prenatal stress and its association with amygdala-related structural covariance patterns in youth
MAREČKOVÁ, Klára, A. MILES, Z.J. LIAO, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL et. al.Basic information
Original name
Prenatal stress and its association with amygdala-related structural covariance patterns in youth
Authors
MAREČKOVÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), A. MILES, Z.J. LIAO, Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution), T. PAUS and Y.S. NIKOLOVA
Edition
NeuroImage: Clinical, Oxford, Elsevier BV, 2022, 2213-1582
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.200
RIV identification code
RIV/00216224:14740/22:00125610
Organization unit
Central European Institute of Technology
UT WoS
000790409500011
Keywords in English
Prenatal stress; Structural covariance; Amygdala; Degree centrality; ELSPAC; ALSPAC
Tags
International impact, Reviewed
Změněno: 10/10/2024 09:58, Ing. Jana Kuchtová
Abstract
V originále
Background: Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared plasticity among regions. Childhood trauma is associated with amygdalacentric SCN reorganization patterns, however, the impact of prenatal stress on SCN properties remains unknown. Methods: The study included participants from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with archival prenatal stress data and structural MRI acquired in young adulthood (age 23-24). SCNs were constructed based on Freesurfer-extracted volumes of 7 subcortical and 34 cortical regions. We compared amygdala degree centrality, a measure of hubness, between those exposed to high vs. low (median split) prenatal stress, defined by maternal reports of stressful life events during the first (n = 93, 57% female) and second (n = 125, 54% female) half of pregnancy. Group differences were tested across network density thresholds (5-40%) using 10,000 permutations, with sex and intracranial volume as covariates, followed by sex-specific analyses. Finally, we sought to replicate our results in an independent all-male sample (n = 450, age 18-20) from the Avon Longitudinal Study of Parents and Children (ALSPAC). Results: The high-stress during the first half of pregnancy ELSPAC group showed lower amygdala degree particularly in men, who demonstrated this difference at 10 consecutive thresholds, with no significant differences in global network properties. At the lowest significant density threshold, amygdala volume was positively correlated with hippocampus, putamen, rostral anterior and posterior cingulate, transverse temporal, and pericalcarine cortex in the low-stress (p(FDR) < 0.027), but not the high-stress (p(FDR) > 0.882) group. Although amygdala degree was nominally lower across thresholds in the high-stress ALSPAC group, these results were not significant. Conclusion: Unlike childhood trauma, prenatal stress may shift SCN towards a less amygdala-centric SCN pattern, particularly in men. These findings did not replicate in an all-male ALSPAC sample, possibly due to the sample's younger age and lower prenatal stress exposure.
Links
| EF17_043/0009632, research and development project |
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| LM2018121, research and development project |
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| LQ1601, research and development project |
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| NU20J-04-00022, research and development project |
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| 90129, large research infrastructures |
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