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@article{1845497,
author = {Kostolanská, Katarína and Šiprová, Helena and Bartečků, Elis and Juřica, Jan and Řiháček, Ivan and Táborská, Eva and Souček, Miroslav and Peš, Ondřej},
article_location = {PHILADELPHIA},
article_number = {3},
doi = {http://dx.doi.org/10.1097/FTD.0000000000000946},
keywords = {LC MS; hair cortisol; longitudinal; substitution therapy; Bayes modeling},
language = {eng},
issn = {0163-4356},
journal = {THERAPEUTIC DRUG MONITORING},
title = {Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy},
url = {https://journals.lww.com/drug-monitoring/Abstract/9000/Longitudinal_monitoring_of_hair_cortisol_using.98587.aspx},
volume = {44},
year = {2022}
}
TY - JOUR
ID - 1845497
AU - Kostolanská, Katarína - Šiprová, Helena - Bartečků, Elis - Juřica, Jan - Řiháček, Ivan - Táborská, Eva - Souček, Miroslav - Peš, Ondřej
PY - 2022
TI - Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy
JF - THERAPEUTIC DRUG MONITORING
VL - 44
IS - 3
SP - 438-447
EP - 438-447
PB - LIPPINCOTT WILLIAMS & WILKINS
SN - 01634356
KW - LC MS
KW - hair cortisol
KW - longitudinal
KW - substitution therapy
KW - Bayes modeling
UR - https://journals.lww.com/drug-monitoring/Abstract/9000/Longitudinal_monitoring_of_hair_cortisol_using.98587.aspx
N2 - Objective: Currently available methods for endogenous cortisol monitoring in patients with hormonal insufficiency rely on measurements of plasma levels only at a single time point; thus, any kind of chronic exposure to cortisol is challenging to evaluate as it requires collecting samples at different time points. Hair cortisol levels acquired longitudinally better reflected chronic exposure (both cortisol synthesis and deposition) and may significantly contribute to better outcomes in glucocorticoid replacement therapies. Design: Twenty-two patients on cortisol substitution therapy were monitored for plasma, urinary, and hair cortisol levels for 18 months to determine whether hair cortisol may serve as a monitoring option for therapy setting and adjustment. Methods: Plasma and urinary cortisol levels were measured using standardized immunoassay methods, and segmented (∼ 1 cm) hair cortisol levels were monitored by liquid chromatography coupled to mass spectrometry. A log-normal model of the changes over time was proposed, and Bayesian statistics were used to compare plasma, urinary, and hair cortisol levels over 18 months. Results and Conclusions: Hair cortisol levels decreased over time in patients undergoing substitutional therapy. The residual variance of hair cortisol in comparison to plasma or urinary cortisol levels was much lower. Thus, longitudinal monitoring of hair cortisol levels could prove beneficial as a non-invasive tool to reduce the risk of overdosing and improve the overall patient health.
ER -
KOSTOLANSKÁ, Katarína, Helena ŠIPROVÁ, Elis BARTEČKŮ, Jan JUŘICA, Ivan ŘIHÁČEK, Eva TÁBORSKÁ, Miroslav SOUČEK a Ondřej PEŠ. Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy. \textit{THERAPEUTIC DRUG MONITORING}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{} WILKINS, roč.~44, č.~3, s.~438-447. ISSN~0163-4356. doi:10.1097/FTD.0000000000000946. 2022.
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