Longitudinal monitoring of hair cortisol using liquid
chromatography-mass spectrometry to prevent hypercortisolism in
patients undergoing glucocorticoid replacement therapy

J 2022

Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy

KOSTOLANSKÁ, Katarína, Helena ŠIPROVÁ, Elis BARTEČKŮ, Jan JUŘICA, Ivan ŘIHÁČEK et. al.

Basic information

Original name

Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy

Authors

KOSTOLANSKÁ, Katarína (703 Slovakia, belonging to the institution), Helena ŠIPROVÁ (203 Czech Republic), Elis BARTEČKŮ (203 Czech Republic, belonging to the institution), Jan JUŘICA (203 Czech Republic, belonging to the institution), Ivan ŘIHÁČEK (203 Czech Republic), Eva TÁBORSKÁ (203 Czech Republic, belonging to the institution), Miroslav SOUČEK (203 Czech Republic) and Ondřej PEŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

THERAPEUTIC DRUG MONITORING, PHILADELPHIA, LIPPINCOTT WILLIAMS & WILKINS, 2022, 0163-4356

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.500

RIV identification code

RIV/00216224:14110/22:00125625

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1097/FTD.0000000000000946

UT WoS

000793999100013

Keywords in English

LC MS; hair cortisol; longitudinal; substitution therapy; Bayes modeling

Abstract

V originále

Objective: Currently available methods for endogenous cortisol monitoring in patients with hormonal insufficiency rely on measurements of plasma levels only at a single time point; thus, any kind of chronic exposure to cortisol is challenging to evaluate as it requires collecting samples at different time points. Hair cortisol levels acquired longitudinally better reflected chronic exposure (both cortisol synthesis and deposition) and may significantly contribute to better outcomes in glucocorticoid replacement therapies. Design: Twenty-two patients on cortisol substitution therapy were monitored for plasma, urinary, and hair cortisol levels for 18 months to determine whether hair cortisol may serve as a monitoring option for therapy setting and adjustment. Methods: Plasma and urinary cortisol levels were measured using standardized immunoassay methods, and segmented (∼ 1 cm) hair cortisol levels were monitored by liquid chromatography coupled to mass spectrometry. A log-normal model of the changes over time was proposed, and Bayesian statistics were used to compare plasma, urinary, and hair cortisol levels over 18 months. Results and Conclusions: Hair cortisol levels decreased over time in patients undergoing substitutional therapy. The residual variance of hair cortisol in comparison to plasma or urinary cortisol levels was much lower. Thus, longitudinal monitoring of hair cortisol levels could prove beneficial as a non-invasive tool to reduce the risk of overdosing and improve the overall patient health.

Links

MUNI/A/1090/2021, interní kód MU

Name: Příspěvek {bio}chemických metod při studiu molekulární podstaty vybraných patologických jevů a onemocnění

Investor: Masaryk University

MUNI/A/1266/2020, interní kód MU

Name: Příspěvek [bio]chemických metod při studiu molekulární podstaty vybraných patologických jevů a onemocnění

Investor: Masaryk University

ROZV/28/LF11/2020, interní kód MU

Name: Klinické aplikace hmotnostní spektrometrie

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

ROZV/28/LF/2020, interní kód MU

Name: LF - Příspěvek na InstP 2020

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

KOSTOLANSKÁ, Katarína, Helena ŠIPROVÁ, Elis BARTEČKŮ, Jan JUŘICA, Ivan ŘIHÁČEK, Eva TÁBORSKÁ, Miroslav SOUČEK and Ondřej PEŠ. Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy. THERAPEUTIC DRUG MONITORING. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS, 2022, vol. 44, No 3, p. 438-447. ISSN 0163-4356. Available from: https://dx.doi.org/10.1097/FTD.0000000000000946.

@article{1845497,
   author = {Kostolanská, Katarína and Šiprová, Helena and Bartečků, Elis and Juřica, Jan and Řiháček, Ivan and Táborská, Eva and Souček, Miroslav and Peš, Ondřej},
   article_location = {PHILADELPHIA},
   article_number = {3},
   doi = {http://dx.doi.org/10.1097/FTD.0000000000000946},
   keywords = {LC MS; hair cortisol; longitudinal; substitution therapy; Bayes modeling},
   language = {eng},
   issn = {0163-4356},
   journal = {THERAPEUTIC DRUG MONITORING},
   title = {Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy},
   url = {https://journals.lww.com/drug-monitoring/Abstract/9000/Longitudinal_monitoring_of_hair_cortisol_using.98587.aspx},
   volume = {44},
   year = {2022}
}

TY  - JOUR
ID  - 1845497
AU  - Kostolanská, Katarína - Šiprová, Helena - Bartečků, Elis - Juřica, Jan - Řiháček, Ivan - Táborská, Eva - Souček, Miroslav - Peš, Ondřej
PY  - 2022
TI  - Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy
JF  - THERAPEUTIC DRUG MONITORING
VL  - 44
IS  - 3
SP  - 438-447
EP  - 438-447
PB  - LIPPINCOTT WILLIAMS & WILKINS
SN  - 01634356
KW  - LC MS
KW  - hair cortisol
KW  - longitudinal
KW  - substitution therapy
KW  - Bayes modeling
UR  - https://journals.lww.com/drug-monitoring/Abstract/9000/Longitudinal_monitoring_of_hair_cortisol_using.98587.aspx
N2  - Objective: Currently available methods for endogenous cortisol monitoring in patients with hormonal insufficiency rely on measurements of plasma levels only at a single time point; thus, any kind of chronic exposure to cortisol is challenging to evaluate as it requires collecting samples at different time points. Hair cortisol levels acquired longitudinally better reflected chronic exposure (both cortisol synthesis and deposition) and may significantly contribute to better outcomes in glucocorticoid replacement therapies. Design: Twenty-two patients on cortisol substitution therapy were monitored for plasma, urinary, and hair cortisol levels for 18 months to determine whether hair cortisol may serve as a monitoring option for therapy setting and adjustment. Methods: Plasma and urinary cortisol levels were measured using standardized immunoassay methods, and segmented (∼ 1 cm) hair cortisol levels were monitored by liquid chromatography coupled to mass spectrometry. A log-normal model of the changes over time was proposed, and Bayesian statistics were used to compare plasma, urinary, and hair cortisol levels over 18 months. Results and Conclusions: Hair cortisol levels decreased over time in patients undergoing substitutional therapy. The residual variance of hair cortisol in comparison to plasma or urinary cortisol levels was much lower. Thus, longitudinal monitoring of hair cortisol levels could prove beneficial as a non-invasive tool to reduce the risk of overdosing and improve the overall patient health.
ER  -

KOSTOLANSKÁ, Katarína, Helena ŠIPROVÁ, Elis BARTEČKŮ, Jan JUŘICA, Ivan ŘIHÁČEK, Eva TÁBORSKÁ, Miroslav SOUČEK and Ondřej PEŠ. Longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry to prevent hypercortisolism in patients undergoing glucocorticoid replacement therapy. \textit{THERAPEUTIC DRUG MONITORING}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{} WILKINS, 2022, vol.~44, No~3, p.~438-447. ISSN~0163-4356. Available from: https://dx.doi.org/10.1097/FTD.0000000000000946.

Detailed Information on Publication Record