Thermostable FGF2 polypeptide, use thereof

P 2021

Thermostable FGF2 polypeptide, use thereof

DVOŘÁK, Petr, Pavel KREJČÍ, Lukáš BÁLEK, Lívia EISELLEOVÁ, Žaneta KONEČNÁ et. al.

Basic information

Original name

Thermostable FGF2 polypeptide, use thereof

Authors

DVOŘÁK, Petr (203 Czech Republic, belonging to the institution), Pavel KREJČÍ (203 Czech Republic, belonging to the institution), Lukáš BÁLEK (203 Czech Republic, belonging to the institution), Lívia EISELLEOVÁ (703 Slovakia, belonging to the institution), Žaneta KONEČNÁ (203 Czech Republic, belonging to the institution), Pavel DVOŘÁK (203 Czech Republic, belonging to the institution), David BEDNÁŘ (203 Czech Republic, belonging to the institution), Jan BREZOVSKÝ (203 Czech Republic, belonging to the institution), Eva ŠEBESTOVÁ (203 Czech Republic, belonging to the institution), Radka CHALOUPKOVÁ (203 Czech Republic, belonging to the institution), Veronika ŠTĚPÁNKOVÁ, Pavel VAŇÁČEK, Zbyněk PROKOP, Jiří DAMBORSKÝ (203 Czech Republic, belonging to the institution) and Michaela BOSÁKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Number: AU2016359722, Publisher: Australian Patent Office, Place of publication: Australia, Owner's name: Masarykova Univerzita; Enantis s.r.o. 2021

Other information

Language

English

Type of outcome

Patent

Field of Study

10600 1.6 Biological sciences

Country of publisher

Australia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14310/21:00124498

Organization unit

Faculty of Science

Keywords in English

FGF2; Stem cells; Drugs

Abstract

V originále

The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.

Links

LO1214, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

DVOŘÁK, Petr, Pavel KREJČÍ, Lukáš BÁLEK, Lívia EISELLEOVÁ, Žaneta KONEČNÁ, Pavel DVOŘÁK, David BEDNÁŘ, Jan BREZOVSKÝ, Eva ŠEBESTOVÁ, Radka CHALOUPKOVÁ, Veronika ŠTĚPÁNKOVÁ, Pavel VAŇÁČEK, Zbyněk PROKOP, Jiří DAMBORSKÝ and Michaela BOSÁKOVÁ. Thermostable FGF2 polypeptide, use thereof. 2021.

@misc{1845598,
   author = {Dvořák, Petr and Krejčí, Pavel and Bálek, Lukáš and Eiselleová, Lívia and Konečná, Žaneta and Dvořák, Pavel and Bednář, David and Brezovský, Jan and Šebestová, Eva and Chaloupková, Radka and Štěpánková, Veronika and Vaňáček, Pavel and Prokop, Zbyněk and Damborský, Jiří and Bosáková, Michaela},
   keywords = {FGF2; Stem cells; Drugs},
   language = {eng},
   title = {Thermostable FGF2 polypeptide, use thereof},
   url = {https://worldwide.espacenet.com/patent/search/family/054754475/publication/AU2016359722B2?q=pn%3DAU2016359722B2},
   year = {2021}
}

TY  - PAT
ID  - 1845598
AU  - Dvořák, Petr - Krejčí, Pavel - Bálek, Lukáš - Eiselleová, Lívia - Konečná, Žaneta - Dvořák, Pavel - Bednář, David - Brezovský, Jan - Šebestová, Eva - Chaloupková, Radka - Štěpánková, Veronika - Vaňáček, Pavel - Prokop, Zbyněk - Damborský, Jiří - Bosáková, Michaela
PY  - 2021
TI  - Thermostable FGF2 polypeptide, use thereof
KW  - FGF2
KW  - Stem cells
KW  - Drugs
UR  - https://worldwide.espacenet.com/patent/search/family/054754475/publication/AU2016359722B2?q=pn%3DAU2016359722B2
N2  - The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
ER  -

DVOŘÁK, Petr, Pavel KREJČÍ, Lukáš BÁLEK, Lívia EISELLEOVÁ, Žaneta KONEČNÁ, Pavel DVOŘÁK, David BEDNÁŘ, Jan BREZOVSKÝ, Eva ŠEBESTOVÁ, Radka CHALOUPKOVÁ, Veronika ŠTĚPÁNKOVÁ, Pavel VAŇÁČEK, Zbyněk PROKOP, Jiří DAMBORSKÝ and Michaela BOSÁKOVÁ. \textit{Thermostable FGF2 polypeptide, use thereof}. 2021.

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