Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

BARTÁKOVÁ, Julie, Tereza DEISSOVÁ, Simona SLEZÁKOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN, Petra BOŘILOVÁ LINHARTOVÁ, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study. BMC Oral Health. London: BMC, 2022, vol. 22, No 1, p. 1-9. ISSN 1472-6831. Available from: https://dx.doi.org/10.1186/s12903-022-02115-3.

Basic information

• Original name: Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study
• Authors: BARTÁKOVÁ, Julie (203 Czech Republic, belonging to the institution), Tereza DEISSOVÁ (203 Czech Republic, belonging to the institution), Simona SLEZÁKOVÁ (203 Czech Republic, belonging to the institution), Jirina BARTOVA (203 Czech Republic), Jitka PETANOVA (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: BMC Oral Health, London, BMC, 2022, 1472-6831.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30208 Dentistry, oral surgery and medicine
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.900
• RIV identification code: RIV/00216224:14110/22:00125641
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1186/s12903-022-02115-3
• UT WoS: 000770760100002
• Keywords in English: Recurrent aphthous stomatitis; Angiotensin I converting enzyme; Polymorphism; Haplotype; Sex difference
• Tags: 14110130, 14110518, 14119612, 14119613, podil, rivok
• Tags: International impact, Reviewed

Abstract

Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P-corr > 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P < 0.035, P-corr > 0.05, respectively) than in men with RAS (P > 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, P-corr < 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P < 0.00001) and CGI haplotype was less frequent in RAS patients (P < 0.01), especially in women (P = 0.016, P-corr > 0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.

Links

• MUNI/A/1445/2021, interní kód MU: Name: Nemoci dutiny ústní – výzkum jejich etiopatogeneze, diagnostiky a léčebných přístupů

Investor: Masaryk University