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@article{1846770,
author = {Hönigová, Kateřina and Navrátil, Jiří and Peltanová, Barbora and Holcová Polanská, Hana and Raudenská, Martina and Masařík, Michal},
article_location = {Amsterdam},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.bbcan.2022.188705},
keywords = {Cancer metabolism; ;Warburg effect; Glutaminolysis; Mitochondrial bioenergetics; Metabolic symbiosis; Cell death},
language = {eng},
issn = {0304-419X},
journal = {Biochimica et Biophysica Acta (BBA) - Reviews on Cancer},
title = {Metabolic tricks of cancer cells},
url = {https://www.sciencedirect.com/science/article/pii/S0304419X22000300},
volume = {1877},
year = {2022}
}
TY - JOUR
ID - 1846770
AU - Hönigová, Kateřina - Navrátil, Jiří - Peltanová, Barbora - Holcová Polanská, Hana - Raudenská, Martina - Masařík, Michal
PY - 2022
TI - Metabolic tricks of cancer cells
JF - Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
VL - 1877
IS - 3
SP - 1-18
EP - 1-18
PB - Elsevier
SN - 0304419X
KW - Cancer metabolism
KW - ;Warburg effect
KW - Glutaminolysis
KW - Mitochondrial bioenergetics
KW - Metabolic symbiosis
KW - Cell death
UR - https://www.sciencedirect.com/science/article/pii/S0304419X22000300
N2 - One of the characteristics of cancer cells important for tumorigenesis is their metabolic plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic pathways to support the increased energy request due to continuous growth and rapid proliferation. Moreover, selective pressures in the tumor microenvironment, such as hypoxia, acidosis, and competition for resources, force cancer cells to adapt by complete reorganization of their metabolism. In this review, we highlight the characteristics of cancer metabolism and discuss its clinical significance, since overcoming metabolic plasticity of cancer cells is a key objective of modern cancer therapeutics and a better understanding of metabolic reprogramming may lead to the identification of possible targets for cancer therapy.
ER -
HÖNIGOVÁ, Kateřina, Jiří NAVRÁTIL, Barbora PELTANOVÁ, Hana HOLCOVÁ POLANSKÁ, Martina RAUDENSKÁ and Michal MASAŘÍK. Metabolic tricks of cancer cells. \textit{Biochimica et Biophysica Acta (BBA) - Reviews on Cancer}. Amsterdam: Elsevier, 2022, vol.~1877, No~3, p.~1-18. ISSN~0304-419X. Available from: https://dx.doi.org/10.1016/j.bbcan.2022.188705.
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