Metabolic tricks of cancer cells

HÖNIGOVÁ, Kateřina, Jiří NAVRÁTIL, Barbora PELTANOVÁ, Hana HOLCOVÁ POLANSKÁ, Martina RAUDENSKÁ and Michal MASAŘÍK. Metabolic tricks of cancer cells. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. Amsterdam: Elsevier, 2022, vol. 1877, No 3, p. 1-18. ISSN 0304-419X. Available from: https://dx.doi.org/10.1016/j.bbcan.2022.188705.

Basic information

Original name

Metabolic tricks of cancer cells

Authors

HÖNIGOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Jiří NAVRÁTIL (203 Czech Republic, belonging to the institution), Barbora PELTANOVÁ (203 Czech Republic, belonging to the institution), Hana HOLCOVÁ POLANSKÁ (203 Czech Republic, belonging to the institution), Martina RAUDENSKÁ (203 Czech Republic, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, belonging to the institution)

Edition

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Amsterdam, Elsevier, 2022, 0304-419X

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 11.200

RIV identification code

RIV/00216224:14110/22:00125657

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.bbcan.2022.188705

UT WoS

000806557500001

Keywords in English

Cancer metabolism; ;Warburg effect; Glutaminolysis; Mitochondrial bioenergetics; Metabolic symbiosis; Cell death

Tags

14110515, 14110518, rivok

Tags

International impact, Reviewed

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Abstract

V originále

One of the characteristics of cancer cells important for tumorigenesis is their metabolic plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic pathways to support the increased energy request due to continuous growth and rapid proliferation. Moreover, selective pressures in the tumor microenvironment, such as hypoxia, acidosis, and competition for resources, force cancer cells to adapt by complete reorganization of their metabolism. In this review, we highlight the characteristics of cancer metabolism and discuss its clinical significance, since overcoming metabolic plasticity of cancer cells is a key objective of modern cancer therapeutics and a better understanding of metabolic reprogramming may lead to the identification of possible targets for cancer therapy.

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Links

FW03010186, research and development project	Name: Nová biočipová a mikrofluidní diagnostika cirkulujících biomarkerů a farmakogenů u psychiatrických a onkologických onemocnění Investor: Technology Agency of the Czech Republic, Subprograms 1 Technology leaders
GA21-06873S, research and development project	Name: Metabolická symbióza mezi nádorovými buňkami a fibroblasty asociovaných s nádorem u nádorů v oblasti hlavy a krku Investor: Czech Science Foundation
MUNI/A/1391/2021, interní kód MU	Name: Molekulární, buněčná, tkáňová a systémová patofyziologie vybraných komplexních nemocí (Acronym: KOMPLEX_PF) Investor: Masaryk University
NU21-03-00223, research and development project	Name: Vliv metabolického reprogramování fibroblastů asociovaných s nádorem na prognózu pacientů s nádory hlavy a krku Investor: Ministry of Health of the CR, Subprogram 1 - standard