Detailed Information on Publication Record
2021
大腸癌の診断方法
SLABÝ, Ondřej, Petra VYCHYTILOVÁ, Marek SVOBODA and Milana ŠACHLOVÁBasic information
Original name
大腸癌の診断方法
Name (in English)
How to diagnose colorectal cancer
Authors
SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution), Petra VYCHYTILOVÁ (203 Czech Republic, belonging to the institution), Marek SVOBODA (203 Czech Republic, belonging to the institution) and Milana ŠACHLOVÁ (203 Czech Republic)
Edition
Number: JP6989863B2, Owner's name: Masarykova univerzita, Masarykův onkologický ústav, 2021
Other information
Language
Japanese
Type of outcome
Patent
Field of Study
30204 Oncology
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14740/21:00120238
Organization unit
Central European Institute of Technology
Keywords in English
colorectal;cancer;piRNA;miRNA;biomarker;prognosis;body fluid
Tags
Změněno: 13/4/2022 13:20, Mgr. Pavla Foltynová, Ph.D.
V originále
本発明は、大腸癌の診断方法および予後の予測方法に関する。この方法では、ｐｉＲＮＡ−ｈｓａ−５９３７（配列：TCCCTGGTGGTCTAGTGGTTAGGATTCGGCA（配列番号１））と、ｍｉＲ−２３ａ−３ｐ（配列：AUCACAUUGCCAGGGAUUUCC（配列番号３））、ｍｉＲ−２７ａ−３ｐ（配列：UUCACAGUGGCUAAGUUCCGC（配列番号４））、および、ｍｉＲ−１４２−５ｐ（配列：CAUAAAGUAGAAAGCACUACU（配列番号５））から選択される１つ以上のｍｉＲＮＡとを組合せて、バイオマーカーとして使用する。結果として得られる方法は、体液を入力とする。したがって、この方法は、非侵襲的であり、疾患の最初期のステージであっても感度および特異度が高く、費用対効果も高い。
In English
The present invention relates to a method for diagnosing colorectal cancer and a method for predicting prognosis. In this method, piRNA-hsa-5937 (sequence: TCCCTGGTGGTCTAGTGGTTAGGATTCGGCA (SEQ ID NO: 1)), miR-23a-3p (sequence: AUCACAUUGCCAGGGAUUUCC (SEQ ID NO: 3)), miR-27a-3p (sequence: UUCACAGUGGCUAAGUUCCGC (SEQ ID NO: 4)). )) And one or more miRNAs selected from miR-142-5p (SEQ ID NO: CAUAAAGUAGAAAGCACUACU (SEQ ID NO: 5)) are used as biomarkers. The resulting method uses body fluid as input. Therefore, this method is non-invasive, has high sensitivity and specificity even in the earliest stages of the disease, and is cost-effective.
Links
| NT13549, research and development project |
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