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@article{1849259,
author = {Opatřil, Lukáš and Panovský, Roman and MojicaandPisciotti, Mary and Máchal, Jan and Krejčí, Jan and Holeček, Tomáš and Masárová, Lucia and Feitová, Věra and Godava, Július and Kincl, Vladimír and Kepák, Tomáš and Závodná, Gabriela and Špinarová, Lenka},
article_location = {Berlin},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-022-09739-z},
keywords = {Stress pulmonary circulation; cardiovascular magnetic resonance; heart transplant},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant},
url = {https://www.nature.com/articles/s41598-022-09739-z},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 1849259
AU - Opatřil, Lukáš - Panovský, Roman - Mojica-Pisciotti, Mary - Máchal, Jan - Krejčí, Jan - Holeček, Tomáš - Masárová, Lucia - Feitová, Věra - Godava, Július - Kincl, Vladimír - Kepák, Tomáš - Závodná, Gabriela - Špinarová, Lenka
PY - 2022
TI - Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant
JF - Scientific Reports
VL - 12
IS - 1
SP - 1-10
EP - 1-10
PB - Nature
SN - 20452322
KW - Stress pulmonary circulation
KW - cardiovascular magnetic resonance
KW - heart transplant
UR - https://www.nature.com/articles/s41598-022-09739-z
N2 - Rest pulmonary circulation parameters such as pulmonary transit time (PTT), heart rate corrected PTT (PTTc) and pulmonary transit beats (PTB) can be evaluated using several methods, including the first-pass perfusion from cardiovascular magnetic resonance. As previously published, up to 58% of patients after HTx have diastolic dysfunction detectable only in stress conditions. By using adenosine stress perfusion images, stress analogues of the mentioned parameters can be assessed. By dividing stress to rest biomarkers, potential new ratio parameters (PTT ratio and PTTc ratio) can be obtained. The objectives were to (1) provide more evidence about stress pulmonary circulation biomarkers, (2) present stress to rest ratio parameters, and (3) assess these biomarkers in patients with presumed diastolic dysfunction after heart transplant (HTx) and in childhood cancer survivors (CCS) without any signs of diastolic dysfunction. In this retrospective study, 48 patients after HTx, divided into subgroups based on echocardiographic signs of diastolic dysfunction (41 without, 7 with) and 39 CCS were enrolled. PTT was defined as the difference between the onset time of the signal intensity increase in the left and the right ventricle. PTT in rest conditions were without significant differences when comparing the CCS and HTx subgroup without diastolic dysfunction (4.96 ± 0.93 s vs. 5.51 ± 1.14 s, p = 0.063) or with diastolic dysfunction (4.96 ± 0.93 s vs. 6.04 ± 1.13 s, p = 0.13). However, in stress conditions, both PTT and PTTc were significantly lower in the CCS group than in the HTx subgroups, (PTT: 3.76 ± 0.78 s vs. 4.82 ± 1.03 s, p < 0.001; 5.52 ± 1.56 s, p = 0.002). PTT ratio and PTTc ratio were below 1 in all groups. In conclusion, stress pulmonary circulation parameters obtained from CMR showed prolonged PTT and PTTc in HTx groups compared to CCS, which corresponds with the presumption of underlying diastolic dysfunction. The ratio parameters were less than 1.
ER -
OPATŘIL, Lukáš, Roman PANOVSKÝ, Mary MOJICA-PISCIOTTI, Jan MÁCHAL, Jan KREJČÍ, Tomáš HOLEČEK, Lucia MASÁROVÁ, Věra FEITOVÁ, Július GODAVA, Vladimír KINCL, Tomáš KEPÁK, Gabriela ZÁVODNÁ and Lenka ŠPINAROVÁ. Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant. \textit{Scientific Reports}. Berlin: Nature, 2022, vol.~12, No~1, p.~1-10. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-09739-z.
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