J 2022

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

OPATŘIL, Lukáš, Roman PANOVSKÝ, Mary MOJICA-PISCIOTTI, Jan MÁCHAL, Jan KREJČÍ et. al.

Basic information

Original name

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

Authors

OPATŘIL, Lukáš (203 Czech Republic, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, guarantor, belonging to the institution), Mary MOJICA-PISCIOTTI, Jan MÁCHAL (203 Czech Republic, belonging to the institution), Jan KREJČÍ (203 Czech Republic, belonging to the institution), Tomáš HOLEČEK (203 Czech Republic), Lucia MASÁROVÁ (703 Slovakia, belonging to the institution), Věra FEITOVÁ (203 Czech Republic), Július GODAVA (703 Slovakia), Vladimír KINCL (203 Czech Republic, belonging to the institution), Tomáš KEPÁK (203 Czech Republic), Gabriela ZÁVODNÁ (203 Czech Republic, belonging to the institution) and Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution)

Edition

Scientific Reports, Berlin, Nature, 2022, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14110/22:00125708

Organization unit

Faculty of Medicine

DOI

UT WoS

000782202600081

Keywords in English

Stress pulmonary circulation; cardiovascular magnetic resonance; heart transplant

Tags

Tags

International impact, Reviewed
Změněno: 19/7/2022 13:08, Mgr. Tereza Miškechová

Abstract

V originále

Rest pulmonary circulation parameters such as pulmonary transit time (PTT), heart rate corrected PTT (PTTc) and pulmonary transit beats (PTB) can be evaluated using several methods, including the first-pass perfusion from cardiovascular magnetic resonance. As previously published, up to 58% of patients after HTx have diastolic dysfunction detectable only in stress conditions. By using adenosine stress perfusion images, stress analogues of the mentioned parameters can be assessed. By dividing stress to rest biomarkers, potential new ratio parameters (PTT ratio and PTTc ratio) can be obtained. The objectives were to (1) provide more evidence about stress pulmonary circulation biomarkers, (2) present stress to rest ratio parameters, and (3) assess these biomarkers in patients with presumed diastolic dysfunction after heart transplant (HTx) and in childhood cancer survivors (CCS) without any signs of diastolic dysfunction. In this retrospective study, 48 patients after HTx, divided into subgroups based on echocardiographic signs of diastolic dysfunction (41 without, 7 with) and 39 CCS were enrolled. PTT was defined as the difference between the onset time of the signal intensity increase in the left and the right ventricle. PTT in rest conditions were without significant differences when comparing the CCS and HTx subgroup without diastolic dysfunction (4.96 ± 0.93 s vs. 5.51 ± 1.14 s, p = 0.063) or with diastolic dysfunction (4.96 ± 0.93 s vs. 6.04 ± 1.13 s, p = 0.13). However, in stress conditions, both PTT and PTTc were significantly lower in the CCS group than in the HTx subgroups, (PTT: 3.76 ± 0.78 s vs. 4.82 ± 1.03 s, p < 0.001; 5.52 ± 1.56 s, p = 0.002). PTT ratio and PTTc ratio were below 1 in all groups. In conclusion, stress pulmonary circulation parameters obtained from CMR showed prolonged PTT and PTTc in HTx groups compared to CCS, which corresponds with the presumption of underlying diastolic dysfunction. The ratio parameters were less than 1.