VASILEIOU, K., Jakub VYSLOUŽIL, Miroslava PAVELKOVÁ and Kateřina KUBOVÁ. The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters. Ceska a Slovenska Farmacie. Czech Medical Association J.E. Purkyn, 2017, vol. 66, No 5, p. 274 - 280. ISSN 1210-7816.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters
Authors VASILEIOU, K., Jakub VYSLOUŽIL, Miroslava PAVELKOVÁ and Kateřina KUBOVÁ.
Edition Ceska a Slovenska Farmacie, Czech Medical Association J.E. Purkyn, 2017, 1210-7816.
Other information
Type of outcome Article in a journal
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Science
Keywords (in Czech) Eudragit RS®; Microparticles; Solvent evaporation; Sustained drug release
Changed by Changed by: JUDr. Sabina Krejčiříková, učo 383857. Changed: 5/5/2022 17:45.
Abstract
Size-reduced microparticles were successfully obtained by solvent evaporation method. Different parameters were applied in each sample and their influence on microparticles was evaluated. As a model drug the insoluble ibuprofen was selected for the encapsulation process with Eudragit® RS. The obtained microparticles were inspected by optical microscopy and scanning electron microscopy. The effect of aqueous phase volume (600, 400, 200 ml) and the concentration of polyvinyl alcohol (PVA; 1.0% and 0.1%) were studied. It was evaluated how those variations and also size can affect microparticle characteristics such as encapsulation efficiency, drug loading, burst effect and microparticle morphology. It was observed that the sample prepared with 600 ml aqueous phase and 1% concentration of polyvinyl alcohol gave the most favorable results.
PrintDisplayed: 28/4/2024 12:49