| PELTANOVÁ, Barbora, Hana HOLCOVÁ POLANSKÁ, Martina RAUDENSKÁ, Jan BALVAN, Jiří NAVRÁTIL, Tomáš VIČAR, Jaromír GUMULEC, Barbora ČECHOVÁ, Martin KRÄTER, Jochen GUCK, David KALFEŘT, Marek GREGA, Jan PLZÁK, Jan BETKA and Michal MASAŘÍK. mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells. Cancers. Basel: MDPI, 2022, vol. 14, No 9, p. 1-21. ISSN 2072-6694. Available from: https://dx.doi.org/10.3390/cancers14092286. |
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@article{1852137,
author = {Peltanová, Barbora and Holcová Polanská, Hana and Raudenská, Martina and Balvan, Jan and Navrátil, Jiří and Vičar, Tomáš and Gumulec, Jaromír and Čechová, Barbora and Kräter, Martin and Guck, Jochen and Kalfeřt, David and Grega, Marek and Plzák, Jan and Betka, Jan and Masařík, Michal},
article_location = {Basel},
article_number = {9},
doi = {http://dx.doi.org/10.3390/cancers14092286},
keywords = {cancer; HNSCC; cancer-associated fibroblasts; tumour microenvironment; cell stiffness},
language = {eng},
issn = {2072-6694},
journal = {Cancers},
title = {mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells},
url = {https://www.mdpi.com/2072-6694/14/9/2286},
volume = {14},
year = {2022}
}
TY - JOUR
ID - 1852137
AU - Peltanová, Barbora - Holcová Polanská, Hana - Raudenská, Martina - Balvan, Jan - Navrátil, Jiří - Vičar, Tomáš - Gumulec, Jaromír - Čechová, Barbora - Kräter, Martin - Guck, Jochen - Kalfeřt, David - Grega, Marek - Plzák, Jan - Betka, Jan - Masařík, Michal
PY - 2022
TI - mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells
JF - Cancers
VL - 14
IS - 9
SP - 1-21
EP - 1-21
PB - MDPI
SN - 20726694
KW - cancer
KW - HNSCC
KW - cancer-associated fibroblasts
KW - tumour microenvironment
KW - cell stiffness
UR - https://www.mdpi.com/2072-6694/14/9/2286
N2 - Head and neck squamous cell carcinomas (HNSCC) belong among severe and highly complex malignant diseases showing a high level of heterogeneity and consequently also a variance in therapeutic response, regardless of clinical stage. Our study implies that the progression of HNSCC may be supported by cancer-associated fibroblasts (CAFs) in the tumour microenvironment (TME) and the heterogeneity of this disease may lie in the level of cooperation between CAFs and epithelial cancer cells, as communication between CAFs and epithelial cancer cells seems to be a key factor for the sustained growth of the tumour mass. In this study, we investigated how CAFs derived from tumours of different mRNA subtypes influence the proliferation of cancer cells and their metabolic and biomechanical reprogramming. We also investigated the clinicopathological significance of the expression of these metabolism-related genes in tissue samples of HNSCC patients to identify a possible gene signature typical for HNSCC progression. We found that the right kind of cooperation between cancer cells and CAFs is needed for tumour growth and progression, and only specific mRNA subtypes can support the growth of primary cancer cells or metastases. Specifically, during coculture, cancer cell colony supporting effect and effect of CAFs on cell stiffness of cancer cells are driven by the mRNA subtype of the tumour from which the CAFs are derived. The degree of colony-forming support is reflected in cancer cell glycolysis levels and lactate shuttle-related transporters.
ER -
PELTANOVÁ, Barbora, Hana HOLCOVÁ POLANSKÁ, Martina RAUDENSKÁ, Jan BALVAN, Jiří NAVRÁTIL, Tomáš VIČAR, Jaromír GUMULEC, Barbora ČECHOVÁ, Martin KRÄTER, Jochen GUCK, David KALFEŘT, Marek GREGA, Jan PLZÁK, Jan BETKA and Michal MASAŘÍK. mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells. \textit{Cancers}. Basel: MDPI, 2022, vol.~14, No~9, p.~1-21. ISSN~2072-6694. Available from: https://dx.doi.org/10.3390/cancers14092286.
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