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@article{1852140,
author = {Helán, Martin and Maláska, Jan and Tomandl, Josef and Jarkovský, Jiří and Helánová, Kateřina and Benešová, Klára and Šitina, Michal and Dastych, Milan and Ondrúš, Tomáš and Pávková Goldbergová, Monika and Gál, Roman and Lokaj, Petr and Tomandlová, Marie and Pařenica, Jiří},
article_location = {Basel},
article_number = {4},
doi = {http://dx.doi.org/10.3390/antiox11040640},
keywords = {sepsis; septic shock; oxidative stress; antioxidant; biomarker; soluble endoglin; superoxide dismutase; asymmetric dimethylarginine; neopterin},
language = {eng},
issn = {2076-3921},
journal = {Antioxidants},
title = {Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study},
url = {https://www.mdpi.com/2076-3921/11/4/640},
volume = {11},
year = {2022}
}
TY - JOUR
ID - 1852140
AU - Helán, Martin - Maláska, Jan - Tomandl, Josef - Jarkovský, Jiří - Helánová, Kateřina - Benešová, Klára - Šitina, Michal - Dastych, Milan - Ondrúš, Tomáš - Pávková Goldbergová, Monika - Gál, Roman - Lokaj, Petr - Tomandlová, Marie - Pařenica, Jiří
PY - 2022
TI - Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study
JF - Antioxidants
VL - 11
IS - 4
SP - 1-13
EP - 1-13
PB - MDPI
SN - 20763921
KW - sepsis
KW - septic shock
KW - oxidative stress
KW - antioxidant
KW - biomarker
KW - soluble endoglin
KW - superoxide dismutase
KW - asymmetric dimethylarginine
KW - neopterin
UR - https://www.mdpi.com/2076-3921/11/4/640
N2 - Septic shock is a major cause of mortality in ICU patients, its pathophysiology is complex and not properly understood. Oxidative stress seems to be one of the most important mechanisms of shock progression to multiple organ failure. In the present pilot study, we have analysed eight oxidative-stress-related biomarkers in seven consecutive time points (i.e., the first seven days) in 21 septic shock patients admitted to the ICU. Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2′-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin). Furthermore, we analysed each biomarker’s ability to predict mortality at the time of admission and 12 h after admission. Although a small number of study subjects were recruited, we have identified four promising molecules for further investigation: soluble endoglin, superoxide dismutase, asymmetric dimethylarginine and neopterin.
ER -
HELÁN, Martin, Jan MALÁSKA, Josef TOMANDL, Jiří JARKOVSKÝ, Kateřina HELÁNOVÁ, Klára BENEŠOVÁ, Michal ŠITINA, Milan DASTYCH, Tomáš ONDRÚŠ, Monika PÁVKOVÁ GOLDBERGOVÁ, Roman GÁL, Petr LOKAJ, Marie TOMANDLOVÁ and Jiří PAŘENICA. Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study. \textit{Antioxidants}. Basel: MDPI, 2022, vol.~11, No~4, p.~1-13. ISSN~2076-3921. Available from: https://dx.doi.org/10.3390/antiox11040640.
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