Formulation and Evaluation of Novel Film Wound Dressing Based
on Collagen/Microfibrillated Carboxymethylcellulose Blend

J 2022

Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend

TENOROVÁ, Kateřina, Ruta MASTEIKOVÁ, Sylvie PAVLOKOVÁ, Klára KOSTELANSKÁ, J. BERNATONIENE et. al.

Basic information

Original name

Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend

Authors

TENOROVÁ, Kateřina (203 Czech Republic, guarantor, belonging to the institution), Ruta MASTEIKOVÁ (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution), Klára KOSTELANSKÁ (203 Czech Republic, belonging to the institution), J. BERNATONIENE and David VETCHÝ (203 Czech Republic, belonging to the institution)

Edition

Pharmaceutics, Basel, MDPI, 2022, 1999-4923

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.400

RIV identification code

RIV/00216224:14160/22:00125797

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/pharmaceutics14040782

UT WoS

000786850200001

Keywords in English

film wound dressing; collagen; microfibrillated carboxymethylcellulose; wound healing; blend films; solvent casting method

Abstract

V originále

Collagen is essential as a physiological material in wound healing, so it is often used in wound management, mainly as a lyophilisate. Collagen also has excellent film-forming properties; unfortunately, however, its utilisation as a film wound dressing is limited because of its weak mechanical properties, especially in its wet state. For this reason, modifications or combinations with different materials are investigated. The combination of collagen with partially modified microfibrillar carboxymethylcellulose (CMC), which has not previously been described, provided a new possibility for strengthening collagen films and was the aim of this work. The collagen–CMC films based on three types of collagens, two plasticizers and two collagen. Plasticiser ratios were prepared using the solvent casting method; partially modified CMC served here as both a film-forming agent and a filler, without compromising the transparency of the films. The presence of microfibrils was confirmed microscopically by SEM. Organoleptic and physicochemical evaluation, especially in terms of practical application on wounds, demonstrated that all the samples had satisfactory properties for this purpose even after wetting. All the films retained acidic pH values even after 24 h, with a maximum of 6.27 ± 0.17, and showed a mild degree of swelling, with a maximum of about 6 after 24 h.

Citovat

TENOROVÁ, Kateřina, Ruta MASTEIKOVÁ, Sylvie PAVLOKOVÁ, Klára KOSTELANSKÁ, J. BERNATONIENE and David VETCHÝ. Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend. Pharmaceutics. Basel: MDPI, 2022, vol. 14, No 4, p. 1-15. ISSN 1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics14040782.

@article{1852539,
   author = {Tenorová, Kateřina and Masteiková, Ruta and Pavloková, Sylvie and Kostelanská, Klára and Bernatoniene, J. and Vetchý, David},
   article_location = {Basel},
   article_number = {4},
   doi = {http://dx.doi.org/10.3390/pharmaceutics14040782},
   keywords = {film wound dressing; collagen; microfibrillated carboxymethylcellulose; wound healing; blend films; solvent casting method},
   language = {eng},
   issn = {1999-4923},
   journal = {Pharmaceutics},
   title = {Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend},
   url = {https://www.mdpi.com/1999-4923/14/4/782},
   volume = {14},
   year = {2022}
}

TY  - JOUR
ID  - 1852539
AU  - Tenorová, Kateřina - Masteiková, Ruta - Pavloková, Sylvie - Kostelanská, Klára - Bernatoniene, J. - Vetchý, David
PY  - 2022
TI  - Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend
JF  - Pharmaceutics
VL  - 14
IS  - 4
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 19994923
KW  - film wound dressing
KW  - collagen
KW  - microfibrillated carboxymethylcellulose
KW  - wound healing
KW  - blend films
KW  - solvent casting method
UR  - https://www.mdpi.com/1999-4923/14/4/782
N2  - Collagen is essential as a physiological material in wound healing, so it is often used in wound management, mainly as a lyophilisate. Collagen also has excellent film-forming properties; unfortunately, however, its utilisation as a film wound dressing is limited because of its weak mechanical properties, especially in its wet state. For this reason, modifications or combinations with different materials are investigated. The combination of collagen with partially modified microfibrillar carboxymethylcellulose (CMC), which has not previously been described, provided a new possibility for strengthening collagen films and was the aim of this work. The collagen–CMC films based on three types of collagens, two plasticizers and two collagen. Plasticiser ratios were prepared using the solvent casting method; partially modified CMC served here as both a film-forming agent and a filler, without compromising the transparency of the films. The presence of microfibrils was confirmed microscopically by SEM. Organoleptic and physicochemical evaluation, especially in terms of practical application on wounds, demonstrated that all the samples had satisfactory properties for this purpose even after wetting. All the films retained acidic pH values even after 24 h, with a maximum of 6.27 ± 0.17, and showed a mild degree of swelling, with a maximum of about 6 after 24 h.
ER  -

TENOROVÁ, Kateřina, Ruta MASTEIKOVÁ, Sylvie PAVLOKOVÁ, Klára KOSTELANSKÁ, J. BERNATONIENE and David VETCHÝ. Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend. \textit{Pharmaceutics}. Basel: MDPI, 2022, vol.~14, No~4, p.~1-15. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics14040782.

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