Foodborne fluoxetine impacts the immune response in rainbow
trout (Oncorhynchus mykkis)

J 2022

Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)

VACLAVIK, J., P. SEHONOVA, J. BLAHOVA, D. MEDKOVA, E. POSTULKOVA et. al.

Basic information

Original name

Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)

Authors

VACLAVIK, J., P. SEHONOVA (guarantor), J. BLAHOVA, D. MEDKOVA, E. POSTULKOVA, O. MALY, M. CHARVATOVA, K. STASTNY, J. LENZ, J. MARES, Aleš FRANC (203 Czech Republic, belonging to the institution) and Z. SVOBODOVA

Edition

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, AMSTERDAM, ELSEVIER, 2022, 1382-6689

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.300

RIV identification code

RIV/00216224:14160/22:00125799

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1016/j.etap.2022.103818

UT WoS

000788239300001

Keywords in English

Aquatic pollutants; Fish hematological profile; Fish immune response; Oxidative stress; SSRI

Abstract

V originále

The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, hematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in hematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.

Citovat

VACLAVIK, J., P. SEHONOVA, J. BLAHOVA, D. MEDKOVA, E. POSTULKOVA, O. MALY, M. CHARVATOVA, K. STASTNY, J. LENZ, J. MARES, Aleš FRANC and Z. SVOBODOVA. Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis). ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. AMSTERDAM: ELSEVIER, 2022, vol. 2022, No 90, p. 1-9. ISSN 1382-6689. Available from: https://dx.doi.org/10.1016/j.etap.2022.103818.

@article{1852728,
   author = {Vaclavik, J. and Sehonova, P. and Blahova, J. and Medkova, D. and Postulkova, E. and Maly, O. and Charvatova, M. and Stastny, K. and Lenz, J. and Mares, J. and Franc, Aleš and Svobodova, Z.},
   article_location = {AMSTERDAM},
   article_number = {90},
   doi = {http://dx.doi.org/10.1016/j.etap.2022.103818},
   keywords = {Aquatic pollutants; Fish hematological profile; Fish immune response; Oxidative stress; SSRI},
   language = {eng},
   issn = {1382-6689},
   journal = {ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY},
   title = {Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)},
   url = {https://www.sciencedirect.com/science/article/pii/S1382668922000114?via%3Dihub},
   volume = {2022},
   year = {2022}
}

TY  - JOUR
ID  - 1852728
AU  - Vaclavik, J. - Sehonova, P. - Blahova, J. - Medkova, D. - Postulkova, E. - Maly, O. - Charvatova, M. - Stastny, K. - Lenz, J. - Mares, J. - Franc, Aleš - Svobodova, Z.
PY  - 2022
TI  - Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)
JF  - ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
VL  - 2022
IS  - 90
SP  - 1-9
EP  - 1-9
PB  - ELSEVIER
SN  - 13826689
KW  - Aquatic pollutants
KW  - Fish hematological profile
KW  - Fish immune response
KW  - Oxidative stress
KW  - SSRI
UR  - https://www.sciencedirect.com/science/article/pii/S1382668922000114?via%3Dihub
N2  - The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, hematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in hematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.
ER  -

VACLAVIK, J., P. SEHONOVA, J. BLAHOVA, D. MEDKOVA, E. POSTULKOVA, O. MALY, M. CHARVATOVA, K. STASTNY, J. LENZ, J. MARES, Aleš FRANC and Z. SVOBODOVA. Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis). \textit{ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY}. AMSTERDAM: ELSEVIER, 2022, vol.~2022, No~90, p.~1-9. ISSN~1382-6689. Available from: https://dx.doi.org/10.1016/j.etap.2022.103818.

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