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@article{1852728,
author = {Vaclavik, J. and Sehonova, P. and Blahova, J. and Medkova, D. and Postulkova, E. and Maly, O. and Charvatova, M. and Stastny, K. and Lenz, J. and Mares, J. and Franc, Aleš and Svobodova, Z.},
article_location = {AMSTERDAM},
article_number = {90},
doi = {http://dx.doi.org/10.1016/j.etap.2022.103818},
keywords = {Aquatic pollutants; Fish hematological profile; Fish immune response; Oxidative stress; SSRI},
language = {eng},
issn = {1382-6689},
journal = {ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY},
title = {Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)},
url = {https://www.sciencedirect.com/science/article/pii/S1382668922000114?via%3Dihub},
volume = {2022},
year = {2022}
}
TY - JOUR
ID - 1852728
AU - Vaclavik, J. - Sehonova, P. - Blahova, J. - Medkova, D. - Postulkova, E. - Maly, O. - Charvatova, M. - Stastny, K. - Lenz, J. - Mares, J. - Franc, Aleš - Svobodova, Z.
PY - 2022
TI - Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)
JF - ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
VL - 2022
IS - 90
SP - 1-9
EP - 1-9
PB - ELSEVIER
SN - 13826689
KW - Aquatic pollutants
KW - Fish hematological profile
KW - Fish immune response
KW - Oxidative stress
KW - SSRI
UR - https://www.sciencedirect.com/science/article/pii/S1382668922000114?via%3Dihub
N2 - The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, hematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in hematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.
ER -
VACLAVIK, J., P. SEHONOVA, J. BLAHOVA, D. MEDKOVA, E. POSTULKOVA, O. MALY, M. CHARVATOVA, K. STASTNY, J. LENZ, J. MARES, Aleš FRANC and Z. SVOBODOVA. Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis). \textit{ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY}. AMSTERDAM: ELSEVIER, 2022, vol.~2022, No~90, p.~1-9. ISSN~1382-6689. Available from: https://dx.doi.org/10.1016/j.etap.2022.103818.
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