Nerve-associated Schwann cell precursors contribute
extracutaneous melanocytes to the heart, inner ear,
supraorbital locations and brain meninges

J 2021

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges

KAUCKA, Marketa, Bara SZAROWSKA, Michaela KAVKOVA, Maria Eleni KASTRITI, Polina KAMENEVA et. al.

Basic information

Original name

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges

Authors

KAUCKA, Marketa (203 Czech Republic, guarantor), Bara SZAROWSKA, Michaela KAVKOVA (203 Czech Republic), Maria Eleni KASTRITI, Polina KAMENEVA, Inga SCHMIDT, Lucie PEŠKOVÁ (203 Czech Republic, belonging to the institution), Alberto Joven ARAUS, Andras SIMON, Jozef KAISER (203 Czech Republic) and Igor ADAMEYKO

Edition

CELLULAR AND MOLECULAR LIFE SCIENCES, BASEL, SPRINGER BASEL AG, 2021, 1420-682X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 9.207

RIV identification code

RIV/00216224:14110/21:00124590

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00018-021-03885-9

UT WoS

000674208000001

Keywords in English

Endothelin 3 and endothelin receptor B; Extracutaneous pigment cell; Glial precursor; Hypopigmentation-associated deafness; Peripheral nerves; Targeted recruitment

Abstract

V originále

Melanocytes are pigmented cells residing mostly in the skin and hair follicles of vertebrates, where they contribute to colouration and protection against UV-B radiation. However, the spectrum of their functions reaches far beyond that. For instance, these pigment-producing cells are found inside the inner ear, where they contribute to the hearing function, and in the heart, where they are involved in the electrical conductivity and support the stiffness of cardiac valves. The embryonic origin of such extracutaneous melanocytes is not clear. We took advantage of lineage-tracing experiments combined with 3D visualizations and gene knockout strategies to address this long-standing question. We revealed that Schwann cell precursors are recruited from the local innervation during embryonic development and give rise to extracutaneous melanocytes in the heart, brain meninges, inner ear, and other locations. In embryos with a knockout of the EdnrB receptor, a condition imitating Waardenburg syndrome, we observed only nerve-associated melanoblasts, which failed to detach from the nerves and to enter the inner ear. Finally, we looked into the evolutionary aspects of extracutaneous melanocytes and found that pigment cells are associated mainly with nerves and blood vessels in amphibians and fish. This new knowledge of the nerve-dependent origin of extracutaneous pigment cells might be directly relevant to the formation of extracutaneous melanoma in humans.

Links

90110, large research infrastructures

Name: CzechNanoLab

Citovat

KAUCKA, Marketa, Bara SZAROWSKA, Michaela KAVKOVA, Maria Eleni KASTRITI, Polina KAMENEVA, Inga SCHMIDT, Lucie PEŠKOVÁ, Alberto Joven ARAUS, Andras SIMON, Jozef KAISER and Igor ADAMEYKO. Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges. CELLULAR AND MOLECULAR LIFE SCIENCES. BASEL: SPRINGER BASEL AG, 2021, vol. 78, No 16, p. 6033-6049. ISSN 1420-682X. Available from: https://dx.doi.org/10.1007/s00018-021-03885-9.

@article{1852762,
   author = {Kaucka, Marketa and Szarowska, Bara and Kavkova, Michaela and Kastriti, Maria Eleni and Kameneva, Polina and Schmidt, Inga and Pešková, Lucie and Araus, Alberto Joven and Simon, Andras and Kaiser, Jozef and Adameyko, Igor},
   article_location = {BASEL},
   article_number = {16},
   doi = {http://dx.doi.org/10.1007/s00018-021-03885-9},
   keywords = {Endothelin 3 and endothelin receptor B; Extracutaneous pigment cell; Glial precursor; Hypopigmentation-associated deafness; Peripheral nerves; Targeted recruitment},
   language = {eng},
   issn = {1420-682X},
   journal = {CELLULAR AND MOLECULAR LIFE SCIENCES},
   title = {Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges},
   url = {https://link.springer.com/article/10.1007/s00018-021-03885-9},
   volume = {78},
   year = {2021}
}

TY  - JOUR
ID  - 1852762
AU  - Kaucka, Marketa - Szarowska, Bara - Kavkova, Michaela - Kastriti, Maria Eleni - Kameneva, Polina - Schmidt, Inga - Pešková, Lucie - Araus, Alberto Joven - Simon, Andras - Kaiser, Jozef - Adameyko, Igor
PY  - 2021
TI  - Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges
JF  - CELLULAR AND MOLECULAR LIFE SCIENCES
VL  - 78
IS  - 16
SP  - 6033-6049
EP  - 6033-6049
PB  - SPRINGER BASEL AG
SN  - 1420682X
KW  - Endothelin 3 and endothelin receptor B
KW  - Extracutaneous pigment cell
KW  - Glial precursor
KW  - Hypopigmentation-associated deafness
KW  - Peripheral nerves
KW  - Targeted recruitment
UR  - https://link.springer.com/article/10.1007/s00018-021-03885-9
N2  - Melanocytes are pigmented cells residing mostly in the skin and hair follicles of vertebrates, where they contribute to colouration and protection against UV-B radiation. However, the spectrum of their functions reaches far beyond that. For instance, these pigment-producing cells are found inside the inner ear, where they contribute to the hearing function, and in the heart, where they are involved in the electrical conductivity and support the stiffness of cardiac valves. The embryonic origin of such extracutaneous melanocytes is not clear. We took advantage of lineage-tracing experiments combined with 3D visualizations and gene knockout strategies to address this long-standing question. We revealed that Schwann cell precursors are recruited from the local innervation during embryonic development and give rise to extracutaneous melanocytes in the heart, brain meninges, inner ear, and other locations. In embryos with a knockout of the EdnrB receptor, a condition imitating Waardenburg syndrome, we observed only nerve-associated melanoblasts, which failed to detach from the nerves and to enter the inner ear. Finally, we looked into the evolutionary aspects of extracutaneous melanocytes and found that pigment cells are associated mainly with nerves and blood vessels in amphibians and fish. This new knowledge of the nerve-dependent origin of extracutaneous pigment cells might be directly relevant to the formation of extracutaneous melanoma in humans.
ER  -

KAUCKA, Marketa, Bara SZAROWSKA, Michaela KAVKOVA, Maria Eleni KASTRITI, Polina KAMENEVA, Inga SCHMIDT, Lucie PEŠKOVÁ, Alberto Joven ARAUS, Andras SIMON, Jozef KAISER and Igor ADAMEYKO. Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges. \textit{CELLULAR AND MOLECULAR LIFE SCIENCES}. BASEL: SPRINGER BASEL AG, 2021, vol.~78, No~16, p.~6033-6049. ISSN~1420-682X. Available from: https://dx.doi.org/10.1007/s00018-021-03885-9.

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