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@article{1852781, author = {Moravcová, Katarína and Karbanová, Martina and Bretschneider, Maxi Pia and Sovová, Markéta and Ozana, Jaromir and Sovova, Eliska}, article_location = {Basel}, article_number = {10}, doi = {http://dx.doi.org/10.3390/nu14102005}, keywords = {obesity; diabetes mellitus type 2; prevention; digital therapeutics; mobile application; randomized controlled trial; lifestyle intervention; metabolic syndrome; insulin resistance}, language = {eng}, issn = {2072-6643}, journal = {Nutrients}, title = {Comparing Digital Therapeutic Intervention with an Intensive Obesity Management Program: Randomized Controlled Trial}, url = {https://www.mdpi.com/2072-6643/14/10/2005}, volume = {14}, year = {2022} }
TY - JOUR ID - 1852781 AU - Moravcová, Katarína - Karbanová, Martina - Bretschneider, Maxi Pia - Sovová, Markéta - Ozana, Jaromir - Sovova, Eliska PY - 2022 TI - Comparing Digital Therapeutic Intervention with an Intensive Obesity Management Program: Randomized Controlled Trial JF - Nutrients VL - 14 IS - 10 SP - 1-14 EP - 1-14 PB - MDPI SN - 20726643 KW - obesity KW - diabetes mellitus type 2 KW - prevention KW - digital therapeutics KW - mobile application KW - randomized controlled trial KW - lifestyle intervention KW - metabolic syndrome KW - insulin resistance UR - https://www.mdpi.com/2072-6643/14/10/2005 N2 - In this study, we evaluated whether the digital program Vitadio achieves comparable results to those of an intensive in-person lifestyle intervention in obesity management. This is a 12-month prospective, randomized controlled trial. Obese patients with insulin resistance, prediabetes or type 2 diabetes were included. The intervention group (IG) used Vitadio. The control group (CG) received a series of in-person consultations. Body weight and various metabolic parameters were observed and analyzed with ANOVA. The trial is ongoing and the presented findings are preliminary. Among 100 participants (29% men; mean age, 43 years; mean BMI, 40.1 kg/m2), 78 completed 3-month follow-up, and 51 have completed the 6-month follow-up so far. Participants significantly (p < 0.01) reduced body weight at 3 months (IG: −5.9 ± 5.0%; CG: −4.2 ± 5.0%) and 6 months (IG: −6.6±6.1%; CG: −7.1 ± 7.1%), and the difference between groups was not significant. The IG achieved favorable change in body composition; significant improvement in TAG (−0.6 ± 0.9 mmol/l, p < 0.01), HDL (0.1 ± 0.1%, p < 0.05), HbA1c (−0.2 ± 0.5%, p < 0.05) and FG (−0.5 ± 1.5 mmol/l, p < 0.05); and a superior (p = 0.02) HOMA-IR reduction (−2.5 ± 5.2, p < 0.01). The digital intervention achieved comparable results to those of the intensive obesity management program. The results suggest that Vitadio is an effective tool for supporting patients in obesity management and diabetes prevention. ER -
MORAVCOVÁ, Katarína, Martina KARBANOVÁ, Maxi Pia BRETSCHNEIDER, Markéta SOVOVÁ, Jaromir OZANA and Eliska SOVOVA. Comparing Digital Therapeutic Intervention with an Intensive Obesity Management Program: Randomized Controlled Trial. \textit{Nutrients}. Basel: MDPI, 2022, vol.~14, No~10, p.~1-14. ISSN~2072-6643. Available from: https://dx.doi.org/10.3390/nu14102005.
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