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@article{1854520,
author = {Satta, Giannin and Loi, Matte and Becker, Nickolau and Benavente, Yoland and De Sanjose, Sanjos Silvi and Foretová, Lenka and Stainer, Anthon and Maynadie, Mar and Nieters, Alexandr and Meloni, Federic and Pilia, Ilari and Campagna, Marcell and Pau, Marc and Zablotska, Lydia B and Cocco, Pierluigi},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1186/s12940-020-00596-9},
keywords = {Ionizing radiation; Lymphoma; Diffuse large B cell lymphoma; Occupational exposure},
language = {eng},
issn = {1476-069X},
journal = {Environmental health},
title = {Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study},
url = {https://ehjournal.biomedcentral.com/articles/10.1186/s12940-020-00596-9},
volume = {19},
year = {2020}
}
TY - JOUR
ID - 1854520
AU - Satta, Giannin - Loi, Matte - Becker, Nickolau - Benavente, Yoland - De Sanjose, Sanjos Silvi - Foretová, Lenka - Stainer, Anthon - Maynadie, Mar - Nieters, Alexandr - Meloni, Federic - Pilia, Ilari - Campagna, Marcell - Pau, Marc - Zablotska, Lydia B - Cocco, Pierluigi
PY - 2020
TI - Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study
JF - Environmental health
VL - 19
IS - 1
SP - 1-11
EP - 1-11
PB - BMC
SN - 1476069X
KW - Ionizing radiation
KW - Lymphoma
KW - Diffuse large B cell lymphoma
KW - Occupational exposure
UR - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-020-00596-9
N2 - Background Evidence linking risk of lymphoma and B-cell lymphoma subtypes to ionizing radiation is inconclusive, particularly at low exposure levels. Methods We investigated risk of lymphoma (all subtypes), B-cell lymphomas, and its major subtypes, associated with low-level occupational exposure to ionizing radiation, in 2346 lymphoma cases and 2463 controls, who participated in the multicenter EpiLymph case-control study. We developed a job-exposure matrix to estimate exposure to ionizing radiation, distinguishing between internal and external radiation, and we applied it to the lifetime occupational history of study subjects, We calculated the Odds Ratio (OR) and its 95% confidence interval (95% CI) for lymphoma (all subtypes combined), B-cell lymphoma, and its major subtypes using unconditional, polytomous logistic regression adjusting for age, gender, and education. Results We did not observe an association between exposure metrics of external and internal radiation and risk of lymphoma (all subtypes), nor with B-cell lymphoma, or its major subtypes, at the levels regularly experienced in occupational settings. An elevated risk of diffuse large B cell lymphoma was observed among the most likely exposed study subjects with relatively higher exposure intensity, which would be worth further investigation. Conclusions Further investigation is warranted on risk of B cell lymphoma subtypes associated with low-level occupational exposure to external ionizing radiation, and to clarify whether lymphoma should be included among the cancer outcomes related to ionizing radiation.
ER -
SATTA, Giannin, Matte LOI, Nickolau BECKER, Yoland BENAVENTE, Sanjos Silvi DE SANJOSE, Lenka FORETOVÁ, Anthon STAINER, Mar MAYNADIE, Alexandr NIETERS, Federic MELONI, Ilari PILIA, Marcell CAMPAGNA, Marc PAU, Lydia B ZABLOTSKA and Pierluigi COCCO. Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study. \textit{Environmental health}. LONDON: BMC, 2020, vol.~19, No~1, p.~1-11. ISSN~1476-069X. Available from: https://dx.doi.org/10.1186/s12940-020-00596-9.
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