Occupational exposure to organic dust and risk of lymphoma
subtypes in the EPILYMPH case-control study

J 2021

Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study

COCCO, P., G. SATTA, F. MELONI, I. PILIA, F. AHMED et. al.

Basic information

Original name

Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study

Authors

COCCO, P. (guarantor), G. SATTA, F. MELONI, I. PILIA, F. AHMED, N. BECKER, D. CASABONNE, S. DE SANJOSÉ, Lenka FORETOVÁ (203 Czech Republic, belonging to the institution), M. MAYNADIÉ, A. NIETERS, A. STAINES, A. T'MANNETJE, M. ZUCCA, M. G. ENNAS, M. CAMPAGNA, S. DE MATTEIS and Y. BENAVENTE

Edition

SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, HELSINKI, SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH, 2021, 0355-3140

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Finland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.492

RIV identification code

RIV/00216224:14110/21:00124641

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5271/sjweh.3925

UT WoS

000600200200006

Keywords in English

B cell lymphoma; epidemiology; flour dust; Hodgkin lymphoma; leather dust; textile dust; wood dust

Abstract

V originále

Objectives This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts. Methods We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case-control study, conducted in six European countries in 1998-2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any types) groups: wood and textile dusts. Risk was predicted with unconditional regression modeling, adjusted by age, gender, study center, and education. Results We observed a 2.1-fold increase in risk of follicular lymphoma associated with ever exposure to leather dust [95% confidence interval (CI) 1.01-4.20]. After excluding subjects who ever worked in a farm or had ever been exposed to solvents, risk of B-cell lymphoma was elevated in relation to ever exposure to leather dust [odd ratio (OR) 2.2, 95% CI 1.00-4.78], but it was not supported by increasing trends with the exposure metrics. Risk of Hodgkin lymphoma was elevated (OR 2.0, 95% CI 0.95-4.30) for exposure to textile dust, with consistent upward trends by cumulative exposure and three independent exposure metrics combined (P=0.023, and P=0.0068, respectively). Conclusions Future, larger studies might provide further insights into the nature of the association we observed between exposure to textile dust and risk of Hodgkin lymphoma.

Citovat

COCCO, P., G. SATTA, F. MELONI, I. PILIA, F. AHMED, N. BECKER, D. CASABONNE, S. DE SANJOSÉ, Lenka FORETOVÁ, M. MAYNADIÉ, A. NIETERS, A. STAINES, A. T'MANNETJE, M. ZUCCA, M. G. ENNAS, M. CAMPAGNA, S. DE MATTEIS and Y. BENAVENTE. Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study. SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH. HELSINKI: SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH, 2021, vol. 47, No 1, p. 42-51. ISSN 0355-3140. Available from: https://dx.doi.org/10.5271/sjweh.3925.

@article{1854522,
   author = {Cocco, P. and Satta, G. and Meloni, F. and Pilia, I. and Ahmed, F. and Becker, N. and Casabonne, D. and de Sanjosé, S. and Foretová, Lenka and Maynadié, M. and Nieters, A. and Staines, A. and t'Mannetje, A. and Zucca, M. and Ennas, M. G. and Campagna, M. and De Matteis, S. and Benavente, Y.},
   article_location = {HELSINKI},
   article_number = {1},
   doi = {http://dx.doi.org/10.5271/sjweh.3925},
   keywords = {B cell lymphoma; epidemiology; flour dust; Hodgkin lymphoma; leather dust; textile dust; wood dust},
   language = {eng},
   issn = {0355-3140},
   journal = {SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH},
   title = {Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study},
   url = {https://www.sjweh.fi/show_abstract.php?abstract_id=3925},
   volume = {47},
   year = {2021}
}

TY  - JOUR
ID  - 1854522
AU  - Cocco, P. - Satta, G. - Meloni, F. - Pilia, I. - Ahmed, F. - Becker, N. - Casabonne, D. - de Sanjosé, S. - Foretová, Lenka - Maynadié, M. - Nieters, A. - Staines, A. - t'Mannetje, A. - Zucca, M. - Ennas, M. G. - Campagna, M. - De Matteis, S. - Benavente, Y.
PY  - 2021
TI  - Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study
JF  - SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
VL  - 47
IS  - 1
SP  - 42-51
EP  - 42-51
PB  - SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH
SN  - 03553140
KW  - B cell lymphoma
KW  - epidemiology
KW  - flour dust
KW  - Hodgkin lymphoma
KW  - leather dust
KW  - textile dust
KW  - wood dust
UR  - https://www.sjweh.fi/show_abstract.php?abstract_id=3925
N2  - Objectives This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts. Methods We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case-control study, conducted in six European countries in 1998-2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any types) groups: wood and textile dusts. Risk was predicted with unconditional regression modeling, adjusted by age, gender, study center, and education. Results We observed a 2.1-fold increase in risk of follicular lymphoma associated with ever exposure to leather dust [95% confidence interval (CI) 1.01-4.20]. After excluding subjects who ever worked in a farm or had ever been exposed to solvents, risk of B-cell lymphoma was elevated in relation to ever exposure to leather dust [odd ratio (OR) 2.2, 95% CI 1.00-4.78], but it was not supported by increasing trends with the exposure metrics. Risk of Hodgkin lymphoma was elevated (OR 2.0, 95% CI 0.95-4.30) for exposure to textile dust, with consistent upward trends by cumulative exposure and three independent exposure metrics combined (P=0.023, and P=0.0068, respectively). Conclusions Future, larger studies might provide further insights into the nature of the association we observed between exposure to textile dust and risk of Hodgkin lymphoma.
ER  -

COCCO, P., G. SATTA, F. MELONI, I. PILIA, F. AHMED, N. BECKER, D. CASABONNE, S. DE SANJOSÉ, Lenka FORETOVÁ, M. MAYNADIÉ, A. NIETERS, A. STAINES, A. T'MANNETJE, M. ZUCCA, M. G. ENNAS, M. CAMPAGNA, S. DE MATTEIS and Y. BENAVENTE. Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study. \textit{SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT \&{} HEALTH}. HELSINKI: SCANDINAVIAN JOURNAL WORK ENVIRONMENT \&{} HEALTH, 2021, vol.~47, No~1, p.~42-51. ISSN~0355-3140. Available from: https://dx.doi.org/10.5271/sjweh.3925.

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