| SAXENA, Sandee, Surabh RUIA, Senthamiz PRASAD, Asth JAIN, Nibh MISHRA, Shankar M NATU, Carsten H MEYER, Jagjit S GILHOTRA, Peter KRUŽLIAK and Levent AKDUMAN. INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS. Retina - The Journal of Retinal and Vitreous Diseases. USA: Lippincott Williams & Wilkins, 2017, vol. 37, No 2, p. 344-349. ISSN 0275-004X. |
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@article{1854524,
author = {Saxena, Sandee and Ruia, Surabh and Prasad, Senthamiz and Jain, Asth and Mishra, Nibh and Natu, Shankar M and Meyer, Carsten H and Gilhotra, Jagjit S and Kružliak, Peter and Akduman, Levent},
article_location = {USA},
article_number = {2},
keywords = {diabetic retinopathy; diabetes mellitus; ellipsoid zone; external limiting membrane; nephropathy; serum creatinine; spectral-domain optical coherence tomography; serum urea},
language = {eng},
issn = {0275-004X},
journal = {Retina - The Journal of Retinal and Vitreous Diseases},
title = {INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS},
url = {https://www.ingentaconnect.com/content/wk/iae/2017/00000037/00000002/art00024},
volume = {37},
year = {2017}
}
TY - JOUR
ID - 1854524
AU - Saxena, Sandee - Ruia, Surabh - Prasad, Senthamiz - Jain, Asth - Mishra, Nibh - Natu, Shankar M - Meyer, Carsten H - Gilhotra, Jagjit S - Kružliak, Peter - Akduman, Levent
PY - 2017
TI - INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS
JF - Retina - The Journal of Retinal and Vitreous Diseases
VL - 37
IS - 2
SP - 344-349
EP - 344-349
PB - Lippincott Williams & Wilkins
SN - 0275004X
KW - diabetic retinopathy
KW - diabetes mellitus
KW - ellipsoid zone
KW - external limiting membrane
KW - nephropathy
KW - serum creatinine
KW - spectral-domain optical coherence tomography
KW - serum urea
UR - https://www.ingentaconnect.com/content/wk/iae/2017/00000037/00000002/art00024
N2 - Purpose: To evaluate the role of serum urea and creatinine as surrogate markers for disruption of retinal photoreceptor external limiting membrane (ELM) and inner segment ellipsoid zone (EZ) in Type 2 diabetic retinopathy (DR) using spectral-domain optical coherence tomography, for the first time. Methods: One hundred and seventeen consecutive cases of Type 2 diabetes mellitus (diabetes without retinopathy [No DR; n = 39], nonproliferative diabetic retinopathy [NPDR; n = 39], proliferative diabetic retinopathy [PDR; n = 39]) and 40 healthy control subjects were included. Serum levels of urea and creatinine were assessed using standard protocol. Spectral-domain optical coherence tomography was used to grade the disruption of ELM and EZ as follows: Grade 0, no disruption of ELM and EZ; Grade 1, ELM disrupted, EZ intact; Grade 2, ELM and EZ disrupted. Data were analyzed statistically. Results: Increase in serum levels of urea (F = 22.93) and creatinine (F = 15.82) and increased grades of disruption of ELM and EZ (gamma = 116.3) were observed with increased severity of DR (P < 0.001). Increase in serum levels of urea (F = 10.45) and creatinine (F = 6.89) was observed with increased grades of disruption of ELM and EZ (P = 0.001). Conclusion: Serum levels of urea and creatinine are surrogate markers for disruption of retinal photoreceptor ELM and EZ on spectral-domain optical coherence tomography in DR.
ER -
SAXENA, Sandee, Surabh RUIA, Senthamiz PRASAD, Asth JAIN, Nibh MISHRA, Shankar M NATU, Carsten H MEYER, Jagjit S GILHOTRA, Peter KRUŽLIAK and Levent AKDUMAN. INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS. \textit{Retina - The Journal of Retinal and Vitreous Diseases}. USA: Lippincott Williams \&{} Wilkins, 2017, vol.~37, No~2, p.~344-349. ISSN~0275-004X.
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