INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE
MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL
LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2
DIABETES MELLITUS

J 2017

INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS

SAXENA, Sandee, Surabh RUIA, Senthamiz PRASAD, Asth JAIN, Nibh MISHRA et. al.

Basic information

Original name

INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS

Authors

SAXENA, Sandee (guarantor), Surabh RUIA, Senthamiz PRASAD, Asth JAIN, Nibh MISHRA, Shankar M NATU, Carsten H MEYER, Jagjit S GILHOTRA, Peter KRUŽLIAK (703 Slovakia, belonging to the institution) and Levent AKDUMAN

Edition

Retina - The Journal of Retinal and Vitreous Diseases, USA, Lippincott Williams & Wilkins, 2017, 0275-004X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30212 Surgery

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.013

RIV identification code

RIV/00216224:14110/17:00124643

Organization unit

Faculty of Medicine

UT WoS

000393671400024

Keywords in English

diabetic retinopathy; diabetes mellitus; ellipsoid zone; external limiting membrane; nephropathy; serum creatinine; spectral-domain optical coherence tomography; serum urea

Abstract

V originále

Purpose: To evaluate the role of serum urea and creatinine as surrogate markers for disruption of retinal photoreceptor external limiting membrane (ELM) and inner segment ellipsoid zone (EZ) in Type 2 diabetic retinopathy (DR) using spectral-domain optical coherence tomography, for the first time. Methods: One hundred and seventeen consecutive cases of Type 2 diabetes mellitus (diabetes without retinopathy [No DR; n = 39], nonproliferative diabetic retinopathy [NPDR; n = 39], proliferative diabetic retinopathy [PDR; n = 39]) and 40 healthy control subjects were included. Serum levels of urea and creatinine were assessed using standard protocol. Spectral-domain optical coherence tomography was used to grade the disruption of ELM and EZ as follows: Grade 0, no disruption of ELM and EZ; Grade 1, ELM disrupted, EZ intact; Grade 2, ELM and EZ disrupted. Data were analyzed statistically. Results: Increase in serum levels of urea (F = 22.93) and creatinine (F = 15.82) and increased grades of disruption of ELM and EZ (gamma = 116.3) were observed with increased severity of DR (P < 0.001). Increase in serum levels of urea (F = 10.45) and creatinine (F = 6.89) was observed with increased grades of disruption of ELM and EZ (P = 0.001). Conclusion: Serum levels of urea and creatinine are surrogate markers for disruption of retinal photoreceptor ELM and EZ on spectral-domain optical coherence tomography in DR.

Citovat

SAXENA, Sandee, Surabh RUIA, Senthamiz PRASAD, Asth JAIN, Nibh MISHRA, Shankar M NATU, Carsten H MEYER, Jagjit S GILHOTRA, Peter KRUŽLIAK and Levent AKDUMAN. INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS. Retina - The Journal of Retinal and Vitreous Diseases. USA: Lippincott Williams & Wilkins, 2017, vol. 37, No 2, p. 344-349. ISSN 0275-004X.

@article{1854524,
   author = {Saxena, Sandee and Ruia, Surabh and Prasad, Senthamiz and Jain, Asth and Mishra, Nibh and Natu, Shankar M and Meyer, Carsten H and Gilhotra, Jagjit S and Kružliak, Peter and Akduman, Levent},
   article_location = {USA},
   article_number = {2},
   keywords = {diabetic retinopathy; diabetes mellitus; ellipsoid zone; external limiting membrane; nephropathy; serum creatinine; spectral-domain optical coherence tomography; serum urea},
   language = {eng},
   issn = {0275-004X},
   journal = {Retina - The Journal of Retinal and Vitreous Diseases},
   title = {INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS},
   url = {https://www.ingentaconnect.com/content/wk/iae/2017/00000037/00000002/art00024},
   volume = {37},
   year = {2017}
}

TY  - JOUR
ID  - 1854524
AU  - Saxena, Sandee - Ruia, Surabh - Prasad, Senthamiz - Jain, Asth - Mishra, Nibh - Natu, Shankar M - Meyer, Carsten H - Gilhotra, Jagjit S - Kružliak, Peter - Akduman, Levent
PY  - 2017
TI  - INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS
JF  - Retina - The Journal of Retinal and Vitreous Diseases
VL  - 37
IS  - 2
SP  - 344-349
EP  - 344-349
PB  - Lippincott Williams & Wilkins
SN  - 0275004X
KW  - diabetic retinopathy
KW  - diabetes mellitus
KW  - ellipsoid zone
KW  - external limiting membrane
KW  - nephropathy
KW  - serum creatinine
KW  - spectral-domain optical coherence tomography
KW  - serum urea
UR  - https://www.ingentaconnect.com/content/wk/iae/2017/00000037/00000002/art00024
N2  - Purpose: To evaluate the role of serum urea and creatinine as surrogate markers for disruption of retinal photoreceptor external limiting membrane (ELM) and inner segment ellipsoid zone (EZ) in Type 2 diabetic retinopathy (DR) using spectral-domain optical coherence tomography, for the first time. Methods: One hundred and seventeen consecutive cases of Type 2 diabetes mellitus (diabetes without retinopathy [No DR; n = 39], nonproliferative diabetic retinopathy [NPDR; n = 39], proliferative diabetic retinopathy [PDR; n = 39]) and 40 healthy control subjects were included. Serum levels of urea and creatinine were assessed using standard protocol. Spectral-domain optical coherence tomography was used to grade the disruption of ELM and EZ as follows: Grade 0, no disruption of ELM and EZ; Grade 1, ELM disrupted, EZ intact; Grade 2, ELM and EZ disrupted. Data were analyzed statistically. Results: Increase in serum levels of urea (F = 22.93) and creatinine (F = 15.82) and increased grades of disruption of ELM and EZ (gamma = 116.3) were observed with increased severity of DR (P < 0.001). Increase in serum levels of urea (F = 10.45) and creatinine (F = 6.89) was observed with increased grades of disruption of ELM and EZ (P = 0.001). Conclusion: Serum levels of urea and creatinine are surrogate markers for disruption of retinal photoreceptor ELM and EZ on spectral-domain optical coherence tomography in DR.
ER  -

SAXENA, Sandee, Surabh RUIA, Senthamiz PRASAD, Asth JAIN, Nibh MISHRA, Shankar M NATU, Carsten H MEYER, Jagjit S GILHOTRA, Peter KRUŽLIAK and Levent AKDUMAN. INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS. \textit{Retina - The Journal of Retinal and Vitreous Diseases}. USA: Lippincott Williams \&{} Wilkins, 2017, vol.~37, No~2, p.~344-349. ISSN~0275-004X.

Detailed Information on Publication Record