Association of ionizing radiation dose from common medical
diagnostic procedures and lymphoma risk in the Epilymph
case-control study

J 2020

Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study

PASQUAL, Elisa, Michelle C. TURNER, Esther GRACIA-LAVEDAN, Delphine CASABONNE, Yolanda BENAVENTE et. al.

Basic information

Original name

Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study

Authors

PASQUAL, Elisa (guarantor), Michelle C. TURNER, Esther GRACIA-LAVEDAN, Delphine CASABONNE, Yolanda BENAVENTE, Isabelle Thierry CHEF, Marc MAYNADIE, Pierluigi COCCO, Anthony STAINER, Lenka FORETOVÁ (203 Czech Republic, belonging to the institution), Alexandra NIETERS, Paolo BOFFETTS, Paul BRENNAN, Elisabeth CARDIS and Silvia DE SANJOSE

Edition

Plos one, San Francisco, Public Library of Science, 2020, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.240

RIV identification code

RIV/00216224:14110/20:00124646

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0235658

UT WoS

000552603900025

Keywords in English

lymphoma; ionizing radiation dose

Abstract

V originále

Medical diagnostic X-rays are an important source of ionizing radiation (IR) exposure in the general population; however, it is unclear if the resulting low patient doses increase lymphoma risk. We examined the association between lifetime medical diagnostic X-ray dose and lymphoma risk, taking into account potential confounding factors, including medical history. The international Epilymph study (conducted in the Czech-Republic, France, Germany, Ireland, Italy, and Spain) collected self-reported information on common diagnostic X-ray procedures from 2,362 lymphoma cases and 2,465 frequency-matched (age, sex, country) controls. Individual lifetime cumulative bone marrow (BM) dose was estimated using time period-based dose estimates for different procedures and body parts. The association between categories of BM dose and lymphoma risk was examined using unconditional logistic regression models adjusting for matching factors, socioeconomic variables, and the presence of underlying medical conditions (atopic, autoimmune, infectious diseases, osteoarthritis, having had a sick childhood, and family history of lymphoma) as potential confounders of the association. Cumulative BM dose was low (median 2.25 mGy) and was not positively associated with lymphoma risk. Odds ratios (ORs) were consistently less than 1.0 in all dose categories compared to the reference category (less than 1 mGy). Results were similar after adjustment for potential confounding factors, when using different exposure scenarios, and in analyses by lymphoma subtype and by type of control (hospital-, population-based). Overall no increased risk of lymphoma was observed. The reduced ORs may be related to unmeasured confounding or other sources of systematic bias.We found little evidence that chronic medical conditions confound lymphoma risk and medical radiation associations.

Citovat

PASQUAL, Elisa, Michelle C. TURNER, Esther GRACIA-LAVEDAN, Delphine CASABONNE, Yolanda BENAVENTE, Isabelle Thierry CHEF, Marc MAYNADIE, Pierluigi COCCO, Anthony STAINER, Lenka FORETOVÁ, Alexandra NIETERS, Paolo BOFFETTS, Paul BRENNAN, Elisabeth CARDIS and Silvia DE SANJOSE. Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study. Plos one. San Francisco: Public Library of Science, 2020, vol. 15, No 7, p. 1-19. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0235658.

@article{1854527,
   author = {Pasqual, Elisa and Turner, Michelle C. and GraciaandLavedan, Esther and Casabonne, Delphine and Benavente, Yolanda and Chef, Isabelle Thierry and Maynadie, Marc and Cocco, Pierluigi and Stainer, Anthony and Foretová, Lenka and Nieters, Alexandra and Boffetts, Paolo and Brennan, Paul and Cardis, Elisabeth and de Sanjose, Silvia},
   article_location = {San Francisco},
   article_number = {7},
   doi = {http://dx.doi.org/10.1371/journal.pone.0235658},
   keywords = {lymphoma; ionizing radiation dose},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study},
   url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235658},
   volume = {15},
   year = {2020}
}

TY  - JOUR
ID  - 1854527
AU  - Pasqual, Elisa - Turner, Michelle C. - Gracia-Lavedan, Esther - Casabonne, Delphine - Benavente, Yolanda - Chef, Isabelle Thierry - Maynadie, Marc - Cocco, Pierluigi - Stainer, Anthony - Foretová, Lenka - Nieters, Alexandra - Boffetts, Paolo - Brennan, Paul - Cardis, Elisabeth - de Sanjose, Silvia
PY  - 2020
TI  - Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study
JF  - Plos one
VL  - 15
IS  - 7
SP  - 1-19
EP  - 1-19
PB  - Public Library of Science
SN  - 19326203
KW  - lymphoma
KW  - ionizing radiation dose
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235658
N2  - Medical diagnostic X-rays are an important source of ionizing radiation (IR) exposure in the general population; however, it is unclear if the resulting low patient doses increase lymphoma risk. We examined the association between lifetime medical diagnostic X-ray dose and lymphoma risk, taking into account potential confounding factors, including medical history. The international Epilymph study (conducted in the Czech-Republic, France, Germany, Ireland, Italy, and Spain) collected self-reported information on common diagnostic X-ray procedures from 2,362 lymphoma cases and 2,465 frequency-matched (age, sex, country) controls. Individual lifetime cumulative bone marrow (BM) dose was estimated using time period-based dose estimates for different procedures and body parts. The association between categories of BM dose and lymphoma risk was examined using unconditional logistic regression models adjusting for matching factors, socioeconomic variables, and the presence of underlying medical conditions (atopic, autoimmune, infectious diseases, osteoarthritis, having had a sick childhood, and family history of lymphoma) as potential confounders of the association. Cumulative BM dose was low (median 2.25 mGy) and was not positively associated with lymphoma risk. Odds ratios (ORs) were consistently less than 1.0 in all dose categories compared to the reference category (less than 1 mGy). Results were similar after adjustment for potential confounding factors, when using different exposure scenarios, and in analyses by lymphoma subtype and by type of control (hospital-, population-based). Overall no increased risk of lymphoma was observed. The reduced ORs may be related to unmeasured confounding or other sources of systematic bias.We found little evidence that chronic medical conditions confound lymphoma risk and medical radiation associations.
ER  -

PASQUAL, Elisa, Michelle C. TURNER, Esther GRACIA-LAVEDAN, Delphine CASABONNE, Yolanda BENAVENTE, Isabelle Thierry CHEF, Marc MAYNADIE, Pierluigi COCCO, Anthony STAINER, Lenka FORETOVÁ, Alexandra NIETERS, Paolo BOFFETTS, Paul BRENNAN, Elisabeth CARDIS and Silvia DE SANJOSE. Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study. \textit{Plos one}. San Francisco: Public Library of Science, 2020, vol.~15, No~7, p.~1-19. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0235658.

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