The effects of dietary exposure to Magneli phase titanium
suboxide and titanium dioxide on rainbow trout (Oncorhynchus
mykiss)

J 2022

The effects of dietary exposure to Magneli phase titanium suboxide and titanium dioxide on rainbow trout (Oncorhynchus mykiss)

CALOUDOVA, Hana, Jana BLAHOVA, Jan MARES, Lukas RICHTERA, Aleš FRANC et. al.

Basic information

Original name

The effects of dietary exposure to Magneli phase titanium suboxide and titanium dioxide on rainbow trout (Oncorhynchus mykiss)

Authors

CALOUDOVA, Hana, Jana BLAHOVA, Jan MARES, Lukas RICHTERA, Aleš FRANC (203 Czech Republic, belonging to the institution), Michaela GARAJOVÁ (703 Slovakia, belonging to the institution), Frantisek TICHY, Jiri LENZ, Jana CALOUDOVA, Vladimira ENEVOVA, Pavel KOPEL, Barbora HAVELKOVA, Pavla LAKDAWALA (guarantor) and Zdenka SVOBODOVA

Edition

Chemosphere, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2022, 0045-6535

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 8.800

RIV identification code

RIV/00216224:14160/22:00125864

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1016/j.chemosphere.2022.133689

UT WoS

000791614600007

Keywords in English

Fish; Subchronic; Oxidative stress; Toxicology; Peroral

Abstract

V originále

Magnéli phase titanium suboxides (Magnéli TiOx) are promising, novel materials with superior properties compared to TiO2, they are substoichiometric titanium oxides with the chemical formula TinO2n-1 (where n ≥ 1). In this study, for the first time, subchronic effects of dietary intake of Magnéli TiOx were evaluated and compared with TiO2 particles of similar size, in concentrations 0.1% and 0.01% of feed. The experiment consisted of 38 d of an exposition period and 14 d of a depuration period. Minor effects on plasma biochemical profile and morphological parameters were recorded. A reduced count of leukocytes was found in the blood of both Magnéli TiOx and TiO2 exposed fish, suggesting immunotoxic effects. Erythrocytosis was specific for Magnéli TiOx. Indices of oxidative stress, namely increased lipid peroxidation in liver, increased activity of superoxide dismutase in liver, kidney and gills and glutathione S-transferase (GST) in gills, as well as decreased activity of ceruloplasmin and GST in liver were found predominantly in fish exposed to TiO2. Histopathological examination revealed increased lipid-like vacuolation in the liver, the presence of hyaline droplets in renal tubules and multiplication of mucous glands in the epidermis in both tested substances and intestine damage in TiO2 groups. Overall, in Magnéli TiOx exposed groups, fewer adverse effects compared to TiO2 expositions were recorded. Their wider practical implementation in place of TiO2 is therefore beneficial.

Citovat

CALOUDOVA, Hana, Jana BLAHOVA, Jan MARES, Lukas RICHTERA, Aleš FRANC, Michaela GARAJOVÁ, Frantisek TICHY, Jiri LENZ, Jana CALOUDOVA, Vladimira ENEVOVA, Pavel KOPEL, Barbora HAVELKOVA, Pavla LAKDAWALA and Zdenka SVOBODOVA. The effects of dietary exposure to Magneli phase titanium suboxide and titanium dioxide on rainbow trout (Oncorhynchus mykiss). Chemosphere. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2022, vol. 293, April, p. 1-11. ISSN 0045-6535. Available from: https://dx.doi.org/10.1016/j.chemosphere.2022.133689.

@article{1855318,
   author = {Caloudova, Hana and Blahova, Jana and Mares, Jan and Richtera, Lukas and Franc, Aleš and Garajová, Michaela and Tichy, Frantisek and Lenz, Jiri and Caloudova, Jana and Enevova, Vladimira and Kopel, Pavel and Havelkova, Barbora and Lakdawala, Pavla and Svobodova, Zdenka},
   article_location = {OXFORD},
   article_number = {April},
   doi = {http://dx.doi.org/10.1016/j.chemosphere.2022.133689},
   keywords = {Fish; Subchronic; Oxidative stress; Toxicology; Peroral},
   language = {eng},
   issn = {0045-6535},
   journal = {Chemosphere},
   title = {The effects of dietary exposure to Magneli phase titanium suboxide and titanium dioxide on rainbow trout (Oncorhynchus mykiss)},
   url = {https://www.sciencedirect.com/science/article/pii/S0045653522001825?via%3Dihub},
   volume = {293},
   year = {2022}
}

TY  - JOUR
ID  - 1855318
AU  - Caloudova, Hana - Blahova, Jana - Mares, Jan - Richtera, Lukas - Franc, Aleš - Garajová, Michaela - Tichy, Frantisek - Lenz, Jiri - Caloudova, Jana - Enevova, Vladimira - Kopel, Pavel - Havelkova, Barbora - Lakdawala, Pavla - Svobodova, Zdenka
PY  - 2022
TI  - The effects of dietary exposure to Magneli phase titanium suboxide and titanium dioxide on rainbow trout (Oncorhynchus mykiss)
JF  - Chemosphere
VL  - 293
IS  - April
SP  - 1-11
EP  - 1-11
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00456535
KW  - Fish
KW  - Subchronic
KW  - Oxidative stress
KW  - Toxicology
KW  - Peroral
UR  - https://www.sciencedirect.com/science/article/pii/S0045653522001825?via%3Dihub
N2  - Magnéli phase titanium suboxides (Magnéli TiOx) are promising, novel materials with superior properties compared to TiO2, they are substoichiometric titanium oxides with the chemical formula TinO2n-1 (where n ≥ 1). In this study, for the first time, subchronic effects of dietary intake of Magnéli TiOx were evaluated and compared with TiO2 particles of similar size, in concentrations 0.1% and 0.01% of feed. The experiment consisted of 38 d of an exposition period and 14 d of a depuration period. Minor effects on plasma biochemical profile and morphological parameters were recorded. A reduced count of leukocytes was found in the blood of both Magnéli TiOx and TiO2 exposed fish, suggesting immunotoxic effects. Erythrocytosis was specific for Magnéli TiOx. Indices of oxidative stress, namely increased lipid peroxidation in liver, increased activity of superoxide dismutase in liver, kidney and gills and glutathione S-transferase (GST) in gills, as well as decreased activity of ceruloplasmin and GST in liver were found predominantly in fish exposed to TiO2. Histopathological examination revealed increased lipid-like vacuolation in the liver, the presence of hyaline droplets in renal tubules and multiplication of mucous glands in the epidermis in both tested substances and intestine damage in TiO2 groups. Overall, in Magnéli TiOx exposed groups, fewer adverse effects compared to TiO2 expositions were recorded. Their wider practical implementation in place of TiO2 is therefore beneficial.
ER  -

CALOUDOVA, Hana, Jana BLAHOVA, Jan MARES, Lukas RICHTERA, Aleš FRANC, Michaela GARAJOVÁ, Frantisek TICHY, Jiri LENZ, Jana CALOUDOVA, Vladimira ENEVOVA, Pavel KOPEL, Barbora HAVELKOVA, Pavla LAKDAWALA and Zdenka SVOBODOVA. The effects of dietary exposure to Magneli phase titanium suboxide and titanium dioxide on rainbow trout (Oncorhynchus mykiss). \textit{Chemosphere}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2022, vol.~293, April, p.~1-11. ISSN~0045-6535. Available from: https://dx.doi.org/10.1016/j.chemosphere.2022.133689.

Detailed Information on Publication Record