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@article{1855738, author = {Fathalla, Walid and Pazdera, Pavel and Khalifa, Mohamed E. and Ali, Ibrahim A. I. and El Rayes, Samir M.}, article_location = {Hoboken}, article_number = {5}, doi = {http://dx.doi.org/10.1002/jhet.4435}, keywords = {2-arylquinazolin-4-amines; benzimidoyl isothiocyanic acid derivative; isothiocyanic acid derivative; quinazoline derivative; thiourea derivative}, language = {eng}, issn = {0022-152X}, journal = {Journal of Heterocyclic Chemistry}, title = {Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine}, url = {https://onlinelibrary.wiley.com/doi/10.1002/jhet.4435}, volume = {59}, year = {2022} }
TY - JOUR ID - 1855738 AU - Fathalla, Walid - Pazdera, Pavel - Khalifa, Mohamed E. - Ali, Ibrahim A. I. - El Rayes, Samir M. PY - 2022 TI - Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine JF - Journal of Heterocyclic Chemistry VL - 59 IS - 5 SP - 933-942 EP - 933-942 PB - Wiley SN - 0022152X KW - 2-arylquinazolin-4-amines KW - benzimidoyl isothiocyanic acid derivative KW - isothiocyanic acid derivative KW - quinazoline derivative KW - thiourea derivative UR - https://onlinelibrary.wiley.com/doi/10.1002/jhet.4435 N2 - Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives. ER -
FATHALLA, Walid, Pavel PAZDERA, Mohamed E. KHALIFA, Ibrahim A. I. ALI and Samir M. EL RAYES. Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine. \textit{Journal of Heterocyclic Chemistry}. Hoboken: Wiley, 2022, vol.~59, No~5, p.~933-942. ISSN~0022-152X. Available from: https://dx.doi.org/10.1002/jhet.4435.
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