FATHALLA, Walid, Pavel PAZDERA, Mohamed E. KHALIFA, Ibrahim A. I. ALI and Samir M. EL RAYES. Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine. Journal of Heterocyclic Chemistry. Hoboken: Wiley, 2022, vol. 59, No 5, p. 933-942. ISSN 0022-152X. Available from: https://dx.doi.org/10.1002/jhet.4435.
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Basic information
Original name Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine
Authors FATHALLA, Walid, Pavel PAZDERA (203 Czech Republic, belonging to the institution), Mohamed E. KHALIFA, Ibrahim A. I. ALI and Samir M. EL RAYES.
Edition Journal of Heterocyclic Chemistry, Hoboken, Wiley, 2022, 0022-152X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.400
RIV identification code RIV/00216224:14310/22:00125879
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1002/jhet.4435
UT WoS 000741461000001
Keywords in English 2-arylquinazolin-4-amines; benzimidoyl isothiocyanic acid derivative; isothiocyanic acid derivative; quinazoline derivative; thiourea derivative
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 25/5/2022 10:17.
Abstract
Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.
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