Novel domino synthesis of 2-(2,3.4-substituted phenyl)
quinazolin-4-amine

J 2022

Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine

FATHALLA, Walid, Pavel PAZDERA, Mohamed E. KHALIFA, Ibrahim A. I. ALI, Samir M. EL RAYES et. al.

Basic information

Original name

Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine

Authors

FATHALLA, Walid, Pavel PAZDERA (203 Czech Republic, belonging to the institution), Mohamed E. KHALIFA, Ibrahim A. I. ALI and Samir M. EL RAYES

Edition

Journal of Heterocyclic Chemistry, Hoboken, Wiley, 2022, 0022-152X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10401 Organic chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.400

RIV identification code

RIV/00216224:14310/22:00125879

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1002/jhet.4435

UT WoS

000741461000001

Keywords in English

2-arylquinazolin-4-amines; benzimidoyl isothiocyanic acid derivative; isothiocyanic acid derivative; quinazoline derivative; thiourea derivative

Abstract

V originále

Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.

Citovat

FATHALLA, Walid, Pavel PAZDERA, Mohamed E. KHALIFA, Ibrahim A. I. ALI and Samir M. EL RAYES. Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine. Journal of Heterocyclic Chemistry. Hoboken: Wiley, 2022, vol. 59, No 5, p. 933-942. ISSN 0022-152X. Available from: https://dx.doi.org/10.1002/jhet.4435.

@article{1855738,
   author = {Fathalla, Walid and Pazdera, Pavel and Khalifa, Mohamed E. and Ali, Ibrahim A. I. and El Rayes, Samir M.},
   article_location = {Hoboken},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/jhet.4435},
   keywords = {2-arylquinazolin-4-amines; benzimidoyl isothiocyanic acid derivative; isothiocyanic acid derivative; quinazoline derivative; thiourea derivative},
   language = {eng},
   issn = {0022-152X},
   journal = {Journal of Heterocyclic Chemistry},
   title = {Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/jhet.4435},
   volume = {59},
   year = {2022}
}

TY  - JOUR
ID  - 1855738
AU  - Fathalla, Walid - Pazdera, Pavel - Khalifa, Mohamed E. - Ali, Ibrahim A. I. - El Rayes, Samir M.
PY  - 2022
TI  - Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine
JF  - Journal of Heterocyclic Chemistry
VL  - 59
IS  - 5
SP  - 933-942
EP  - 933-942
PB  - Wiley
SN  - 0022152X
KW  - 2-arylquinazolin-4-amines
KW  - benzimidoyl isothiocyanic acid derivative
KW  - isothiocyanic acid derivative
KW  - quinazoline derivative
KW  - thiourea derivative
UR  - https://onlinelibrary.wiley.com/doi/10.1002/jhet.4435
N2  - Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.
ER  -

FATHALLA, Walid, Pavel PAZDERA, Mohamed E. KHALIFA, Ibrahim A. I. ALI and Samir M. EL RAYES. Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine. \textit{Journal of Heterocyclic Chemistry}. Hoboken: Wiley, 2022, vol.~59, No~5, p.~933-942. ISSN~0022-152X. Available from: https://dx.doi.org/10.1002/jhet.4435.

Detailed Information on Publication Record