The Bisphenols Found in the Ejaculate of Men Does Not Pass
through the Testes

J 2022

The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes

JEŠETA, Michal, Kateřina FRANZOVÁ, Simona MACHYNOVÁ, Jiří KALINA, Jiří KOHOUTEK et. al.

Basic information

Original name

The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes

Authors

JEŠETA, Michal (203 Czech Republic, belonging to the institution), Kateřina FRANZOVÁ (203 Czech Republic, belonging to the institution), Simona MACHYNOVÁ (203 Czech Republic), Jiří KALINA (203 Czech Republic, belonging to the institution), Jiří KOHOUTEK (203 Czech Republic, belonging to the institution), Lenka MEKIŇOVÁ (703 Slovakia, belonging to the institution), Igor CRHA (203 Czech Republic, belonging to the institution), Bartosz KEMPISTY (616 Poland), Marek KAŠÍK (203 Czech Republic, belonging to the institution), Jana ŽÁKOVÁ (203 Czech Republic, belonging to the institution), Pavel VENTRUBA (203 Czech Republic, belonging to the institution) and Jana NAVRÁTILOVÁ (203 Czech Republic, belonging to the institution)

Edition

Toxics, Basel, MDPI, 2022, 2305-6304

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30108 Toxicology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14110/22:00126027

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/toxics10060311

UT WoS

000818158700001

Keywords in English

bisphenol A; bisphenol S; bisphenol F; endocrine disruptors; human; spermatozoa; IVF; vasectomy; biotransformation

Abstract

V originále

Exposure to bisphenols is related to negative effects on male reproduction. The bisphenols exposure is associated with several modes of action including negative impact on the blood–testis barrier (BTB) in testes or direct effect on spermatozoa. Bisphenols have been detected in human seminal plasma, but the possible mechanism of seminal transfer of bisphenols is not clear. Some authors consider the transfer through the blood–testis barrier to be crucial. Therefore, in this work, we compared normozoospermic men and men after vasectomy who have interrupted vas deferens and their ejaculate does not contain testicular products. We measured the concentration of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) in the urine and seminal plasma of these men using liquid chromatography tandem mass spectrometry (LC/MSMS). We found that the ratio of urinary and seminal plasma content of bisphenols did not differ in normozoospermic men or men after vasectomy. From the obtained data, it can be concluded that the pathways of transport of bisphenols into seminal plasma are not primarily through the testicular tissue, but this pathway is applied similarly to other routes of transmission by a corresponding ejaculate volume ratio. To a much greater extent than through testicular tissue, bisphenols enter the seminal plasma mainly as part of the secretions of the accessory glands.

Links

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

EF19_074/0012727, research and development project

Name: MSCAfellow3@MUNI

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

Citovat

JEŠETA, Michal, Kateřina FRANZOVÁ, Simona MACHYNOVÁ, Jiří KALINA, Jiří KOHOUTEK, Lenka MEKIŇOVÁ, Igor CRHA, Bartosz KEMPISTY, Marek KAŠÍK, Jana ŽÁKOVÁ, Pavel VENTRUBA and Jana NAVRÁTILOVÁ. The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes. Toxics. Basel: MDPI, 2022, vol. 10, No 6, p. 1-9. ISSN 2305-6304. Available from: https://dx.doi.org/10.3390/toxics10060311.

@article{1860558,
   author = {Ješeta, Michal and Franzová, Kateřina and Machynová, Simona and Kalina, Jiří and Kohoutek, Jiří and Mekiňová, Lenka and Crha, Igor and Kempisty, Bartosz and Kašík, Marek and Žáková, Jana and Ventruba, Pavel and Navrátilová, Jana},
   article_location = {Basel},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/toxics10060311},
   keywords = {bisphenol A; bisphenol S; bisphenol F; endocrine disruptors; human; spermatozoa; IVF; vasectomy; biotransformation},
   language = {eng},
   issn = {2305-6304},
   journal = {Toxics},
   title = {The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes},
   url = {https://www.mdpi.com/2305-6304/10/6/311},
   volume = {10},
   year = {2022}
}

TY  - JOUR
ID  - 1860558
AU  - Ješeta, Michal - Franzová, Kateřina - Machynová, Simona - Kalina, Jiří - Kohoutek, Jiří - Mekiňová, Lenka - Crha, Igor - Kempisty, Bartosz - Kašík, Marek - Žáková, Jana - Ventruba, Pavel - Navrátilová, Jana
PY  - 2022
TI  - The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes
JF  - Toxics
VL  - 10
IS  - 6
SP  - 1-9
EP  - 1-9
PB  - MDPI
SN  - 23056304
KW  - bisphenol A
KW  - bisphenol S
KW  - bisphenol F
KW  - endocrine disruptors
KW  - human
KW  - spermatozoa
KW  - IVF
KW  - vasectomy
KW  - biotransformation
UR  - https://www.mdpi.com/2305-6304/10/6/311
N2  - Exposure to bisphenols is related to negative effects on male reproduction. The bisphenols exposure is associated with several modes of action including negative impact on the blood–testis barrier (BTB) in testes or direct effect on spermatozoa. Bisphenols have been detected in human seminal plasma, but the possible mechanism of seminal transfer of bisphenols is not clear. Some authors consider the transfer through the blood–testis barrier to be crucial. Therefore, in this work, we compared normozoospermic men and men after vasectomy who have interrupted vas deferens and their ejaculate does not contain testicular products. We measured the concentration of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) in the urine and seminal plasma of these men using liquid chromatography tandem mass spectrometry (LC/MSMS). We found that the ratio of urinary and seminal plasma content of bisphenols did not differ in normozoospermic men or men after vasectomy. From the obtained data, it can be concluded that the pathways of transport of bisphenols into seminal plasma are not primarily through the testicular tissue, but this pathway is applied similarly to other routes of transmission by a corresponding ejaculate volume ratio. To a much greater extent than through testicular tissue, bisphenols enter the seminal plasma mainly as part of the secretions of the accessory glands.
ER  -

JEŠETA, Michal, Kateřina FRANZOVÁ, Simona MACHYNOVÁ, Jiří KALINA, Jiří KOHOUTEK, Lenka MEKIŇOVÁ, Igor CRHA, Bartosz KEMPISTY, Marek KAŠÍK, Jana ŽÁKOVÁ, Pavel VENTRUBA and Jana NAVRÁTILOVÁ. The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes. \textit{Toxics}. Basel: MDPI, 2022, vol.~10, No~6, p.~1-9. ISSN~2305-6304. Available from: https://dx.doi.org/10.3390/toxics10060311.

Detailed Information on Publication Record