The aim of the present study was to evaluate the association between television viewing/physical activity (TVV/PA) interactions and cardiometabolic risk in an adult European population. A total of 2155 subjects (25-64 years) (45.2% males), a random population-based sample were evaluated in Brno, Czechia. TVV was classified as low (<2 h/day), moderate (2-4), and high (>= 4). PA was classified as insufficient, moderate, and high. To assess the independent association of TVV/PA categories with cardiometabolic variables, multiple linear regression was used. After adjustments, significant associations were: High TVV/insufficient PA with body mass index (BMI) (beta = 2.61, SE = 0.63), waist circumference (WC) (beta = 7.52, SE = 1.58), body fat percent (%BF) (beta = 6.24, SE = 1.02), glucose (beta = 0.25, SE = 0.12), triglycerides (beta = 0.18, SE = 0.05), and high density lipoprotein (HDL-c) (beta = -0.10, SE = 0.04); high TVV/moderate PA with BMI (beta = 1.98, SE = 0.45), WC (beta = 5.43, SE = 1.12), %BF (beta = 5.15, SE = 0.72), triglycerides (beta = 0.08, SE = 0.04), total cholesterol (beta = 0.21, SE = 0.10), low density protein (LDL-c) (beta = 0.19, SE = 0.08), and HDL-c (beta = -0.07, SE = 0.03); and moderate TVV/insufficient PA with WC (beta = 2.68, SE = 1.25), %BF (beta = 3.80, SE = 0.81), LDL-c (beta = 0.18, SE = 0.09), and HDL-c (beta = -0.07, SE = 0.03). Independent of PA levels, a higher TVV was associated with higher amounts of adipose tissue. Higher blood glucose and triglycerides were present in subjects with high TVV and insufficient PA, but not in those with high PA alone. These results affirm the independent cardiometabolic risk of sedentary routines even in subjects with high-levels of PA.