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@article{1860587, author = {McLaughlin, Sarah and Sedláková, Veronika and Zhang, Qingzhou and McNeill, Brian and Smyth, David and Seymour, Richard and Davis, Darryl R and Ruel, Marc and Brand, Marjorie and Alarcon, Emilio I and Suuronen, Erik J}, article_location = {Wrinheim}, article_number = {32}, doi = {http://dx.doi.org/10.1002/adfm.202204076}, keywords = {collagen hydrogels; erythroid differentiation regulator 1; methylglyoxal; myocardial infarction; ventricular remodeling}, language = {eng}, issn = {1616-301X}, journal = {Advanced Functional Materials}, title = {Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice}, url = {https://onlinelibrary.wiley.com/doi/10.1002/adfm.202204076}, volume = {32}, year = {2022} }
TY - JOUR ID - 1860587 AU - McLaughlin, Sarah - Sedláková, Veronika - Zhang, Qingzhou - McNeill, Brian - Smyth, David - Seymour, Richard - Davis, Darryl R - Ruel, Marc - Brand, Marjorie - Alarcon, Emilio I - Suuronen, Erik J PY - 2022 TI - Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice JF - Advanced Functional Materials VL - 32 IS - 32 SP - 1-15 EP - 1-15 PB - Wiley-VCH Verlag SN - 1616301X KW - collagen hydrogels KW - erythroid differentiation regulator 1 KW - methylglyoxal KW - myocardial infarction KW - ventricular remodeling UR - https://onlinelibrary.wiley.com/doi/10.1002/adfm.202204076 N2 - Methylglyoxal (MG) production after myocardial infarction (MI) leads to advanced glycation end-product formation, adverse remodeling, and loss of cardiac function. The extracellular matrix (ECM) is a main target for MG glycation. This suggests that ECM-mimicking biomaterial therapies may protect the post-MI environment by removing MG. In this study, mechanisms by which a recombinant human collagen type I hydrogel therapy confers cardioprotection are investigated. One-week post-MI, mice receive intramyocardial injection of hydrogel or PBS. The hydrogel improves border zone contractility after 2 days, which is maintained for 28 days. RNA sequencing shows that hydrogel treatment decreases the expression of erythroid differentiation regulator 1, a factor associated with apoptosis. Hydrogel treatment reduces cardiomyocyte apoptosis and oxidative stress at 2 days with greater myocardial salvage seen at 28 days. The hydrogel located at the epicardial surface is modified by MG, and less MG-modified proteins are observed in the underlying myocardium of hydrogel-treated mice. Biomaterials that can be a target for MG glycation may act as a sponge to remove MG from the myocardium post-MI. This leads to less oxidative stress, greater survival and contractility of cardiomyocytes, which altogether suggests a novel mechanism by which biomaterials improve function of the infarcted heart. ER -
MCLAUGHLIN, Sarah, Veronika SEDLÁKOVÁ, Qingzhou ZHANG, Brian MCNEILL, David SMYTH, Richard SEYMOUR, Darryl R DAVIS, Marc RUEL, Marjorie BRAND, Emilio I ALARCON and Erik J SUURONEN. Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice. \textit{Advanced Functional Materials}. Wrinheim: Wiley-VCH Verlag, 2022, vol.~32, No~32, p.~1-15. ISSN~1616-301X. Available from: https://dx.doi.org/10.1002/adfm.202204076.
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