| LENÁRT, Sára, Peter LENÁRT, Lucia KNOPFOVÁ, Hana KOTASOVÁ, Vendula PELKOVÁ, Veronika SEDLÁKOVÁ, Ondřej VACEK, Jana POKLUDOVÁ, Vladimír ČAN, Jan ŠMARDA, Karel SOUČEK, Aleš HAMPL and Petr BENEŠ. TACSTD2 upregulation is an early reaction to lung infection. Nature Scientific Reports. London: NATURE RESEARCH, 2022, vol. 12, No 1, p. 9583-9597. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-13637-9. |
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@article{1860591,
author = {Lenárt, Sára and Lenárt, Peter and Knopfová, Lucia and Kotasová, Hana and Pelková, Vendula and Sedláková, Veronika and Vacek, Ondřej and Pokludová, Jana and Čan, Vladimír and Šmarda, Jan and Souček, Karel and Hampl, Aleš and Beneš, Petr},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-022-13637-9},
keywords = {INNATE IMMUNE-RESPONSE; NF-KAPPA-B; EXPRESSION ATLAS; VIRAL-INFECTION; BARRIER; CELLS; GENE; IDENTIFICATION; CANCER; MURINE},
language = {eng},
issn = {2045-2322},
journal = {Nature Scientific Reports},
title = {TACSTD2 upregulation is an early reaction to lung infection},
url = {https://www.nature.com/articles/s41598-022-13637-9},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 1860591
AU - Lenárt, Sára - Lenárt, Peter - Knopfová, Lucia - Kotasová, Hana - Pelková, Vendula - Sedláková, Veronika - Vacek, Ondřej - Pokludová, Jana - Čan, Vladimír - Šmarda, Jan - Souček, Karel - Hampl, Aleš - Beneš, Petr
PY - 2022
TI - TACSTD2 upregulation is an early reaction to lung infection
JF - Nature Scientific Reports
VL - 12
IS - 1
SP - 9583
EP - 9583
PB - NATURE RESEARCH
SN - 20452322
KW - INNATE IMMUNE-RESPONSE
KW - NF-KAPPA-B
KW - EXPRESSION ATLAS
KW - VIRAL-INFECTION
KW - BARRIER
KW - CELLS
KW - GENE
KW - IDENTIFICATION
KW - CANCER
KW - MURINE
UR - https://www.nature.com/articles/s41598-022-13637-9
N2 - TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved for cancer therapy, the physiological role of Trop2 is still not fully understood. In this article, we show that TACSTD2/Trop2 expression is evolutionarily conserved in lungs of various vertebrates. By analysis of publicly available transcriptomic data we demonstrate that TACSTD2 level consistently increases in lungs infected with miscellaneous, but mainly viral pathogens. Single cell and subpopulation based transcriptomic data revealed that the major source of TACSTD2 transcript are lung epithelial cells and their progenitors and that TACSTD2 is induced directly in lung epithelial cells following infection. Increase in TACSTD2 expression may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs.
ER -
LENÁRT, Sára, Peter LENÁRT, Lucia KNOPFOVÁ, Hana KOTASOVÁ, Vendula PELKOVÁ, Veronika SEDLÁKOVÁ, Ondřej VACEK, Jana POKLUDOVÁ, Vladimír ČAN, Jan ŠMARDA, Karel SOUČEK, Aleš HAMPL and Petr BENEŠ. TACSTD2 upregulation is an early reaction to lung infection. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2022, vol.~12, No~1, p.~9583-9597. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-13637-9.
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